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Physiology of Thrombospondin
Abstract
Thrombospondin is a large, multifunctional glycoprotein released from activated platelets and secreted by growing cells. It binds to components of the cell surface and extracellular milieu. Thrombospondin probably modulates a number of processes, including aggregation of platelets, formation and lysis of fibrin, adhesion and migration of cells, and progression of cells through the growth cycle. Studies relating thrombospondin to disease processes are just beginning.
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Citations
Cited by
Tolsma, S., Volpert, O., Good, D., Frazier, W., Polverini, P., & Bouck, N. (1993) · The Journal of cell biology · doi:10.1083/jcb.122.2.497 · Cited by 573
Role of the Gut in Lipid Homeostasis
Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
Thrombospondins: structure and regulation of expression
Bornstein, P. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.14.1426766 · Cited by 349
Schultz-Cherry, S., Ribeiro, S., Gentry, L., & Murphy-Ullrich, J. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47086-x · Cited by 272
Murano, S., Thweatt, R., Shmookler Reis, R. J., Jones, R. A., Moerman, E. J., & Goldstein, S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.3905 · Cited by 199
Metadata
- Authors
- Mosher, D. F.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1990-02
- Volume
- 41
- Issue
- 1
- Pages
- 85-97
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2046938785
- Cited by
- 188
- References
- 0
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mosher, D. F. (1990). Physiology of Thrombospondin. Annual Review of Medicine. https://doi.org/10.1146/annurev.me.41.020190.000505
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
