The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Metabolic Surgery to Treat Type 2 Diabetes: Clinical Outcomes and Mechanisms of Action
Abstract
Several gastrointestinal (GI) operations that were designed to promote weight loss can powerfully ameliorate type 2 diabetes mellitus (T2DM). Although T2DM is traditionally viewed as a chronic, relentless disease in which delay of end-organ complications is the major treatment goal, GI surgery offers a novel endpoint: complete disease remission. Ample data confirm the excellent safety and efficacy of conventional bariatric operations—especially Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding—to treat T2DM in severely obese patients. Use of experimental procedures as well as conventional bariatric operations is increasingly being explored in less obese diabetic patients, with generally favorable results, although further assessment of risk:benefit profiles is needed. Mounting evidence indicates that certain operations involving intestinal diversions improve glucose homeostasis through varied mechanisms beyond reduced food intake and body weight, for example by modulating gut hormones. Research to elucidate such mechanisms should facilitate the design of novel pharmacotherapeutics and dedicated antidiabetes GI manipulations. Here we review evidence regarding the use and study of GI surgery to treat T2DM, focusing on available published reports as well as results from the Diabetes Surgery Summit (DSS) in Rome and the World Congress on Interventional Therapies for T2DM in New York City.
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Cites
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
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Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
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Long-term mortality after gastric bypass surgery
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Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients
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Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
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“In a study of 1160 patients undergoing RYGB, one third of those with T2DM were discharged from their surgical hospitalization normoglycemic without diabetes medications, after an average inpatient stay of <3 days (10).”
Self-citationHyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.
Service, G. J., Thompson, G. B., Service, F. J., Andrews, J. C., Collazo-Clavell, M. L., & Lloyd, R. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043690 · Cited by 779
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Cited by
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743
Bariatric Surgery and Long-term Cardiovascular Events
Sjöström, L., Peltonen, M., Jacobson, P., Sjöström, C. D., Karason, K., Wedel, H., Ahlin, S., Anveden, Å., Bengtsson, C., Bergmark, G., et al. (2012) · JAMA · doi:10.1001/jama.2011.1914 · Cited by 1,656
Mechanick, J. I., Youdim, A., Jones, D. B., Garvey, W. T., Hurley, D. L., McMahon, M. M., Heinberg, L. J., Kushner, R., Adams, T. D., Shikora, S., et al. (2013) · Obesity · doi:10.1002/oby.20461 · Cited by 1,650
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Self-citationRubino, F., Nathan, D. M., Eckel, R. H., Schauer, P. R., Alberti, K. G. M. M., Zimmet, P. Z., Del Prato, S., Ji, L., Sadikot, S. M., Herman, W. H., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0236 · Cited by 1,008
Self-citation
Metadata
- Authors
- Rubino, F., Schauer, P. R., Kaplan, L. M., & Cummings, D. E.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2010-02-01
- Volume
- 61
- Issue
- 1
- Pages
- 393-411
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2139080271
- Cited by
- 381
- References
- 18
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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