The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics
Abstract
Polyketides fall into two structural classes: aromatic and complex. The former are built mainly from acetate units through a reiterative process wherein the beta-carbonyl groups formed after each condensation cycle are left largely unreduced. Complex polyketides are composed of acetates, propionates, or butyrates, and the extent of beta-carbonyl reduction varies from one cycle to the next. Two themes for polyketide synthases are emerging. Aromatic PKSs are determined by four to six genes encoding mono- or bifunctional enzymes; one PKS complex is used for all synthesis steps. Complex PKSs are composed of several multifunctional polypeptides that contain enzymatic domains for the condensation and reduction steps; each domain is used at a unique step in the pathways, and the extent of beta-carbonyl processing depends on the functional domains operating at that cycle. Mutations rendering certain domains nonfunctional have been introduced into genes for complex polyketides, resulting in the production of novel molecules.
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Cites
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Cited by
Genetic Contributions to Understanding Polyketide Synthases
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Mycolactone: A Polyketide Toxin from Mycobacterium ulcerans Required for Virulence
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Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.
Brown, D. W., Yu, J. H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., & Leonard, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1418 · Cited by 507
A new pathway for polyketide synthesis in microorganisms
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The Methyl-Branched Fortifications of Mycobacterium tuberculosis
Minnikin, D. E., Kremer, L., Dover, L. G., & Besra, G. S. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00142-4 · Cited by 262
Metadata
- Authors
- Katz, L., & Donadio, S.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1993-10
- Volume
- 47
- Issue
- 1
- Pages
- 875-912
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2172354041
- Cited by
- 371
- References
- 16
- FWCI
- 27.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Katz, L., & Donadio, S. (1993). POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics. Annual Review of Microbiology. https://doi.org/10.1146/annurev.mi.47.100193.004303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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