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GENETICS AND BIOCHEMISTRY OF DEHALOGENATING ENZYMES
Abstract
Microorganisms that can utilize halogenated compounds as a growth substrate generally produce-enzymes whose function is carbon-halogen bond cleavage. Based on substrate range, reaction type and gene sequences, the dehalogenating enzymes can be classified in different groups, including hydrolytic dehalogenases, glutathione transferases, monooxygenases and hydratases. X-ray crystallographic and biochemical studies have provided detailed mechanistic insight into the action of haloalkane dehalogenase. The essential features are nucleophilic substitution of the halogen by a carboxylate group and the presence of a distinct halogen binding site, formed by tryptophan residues. This review summaries current knowledge on a variety of other dehalogenating enzymes and indicates the existence of a widespread and diverse microbial potential for dechlorination of natural and xenobiotic halogenated compounds.
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Cited by
BIODEGRADATION OF NITROAROMATIC COMPOUNDS
Spain, J. C. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.002515 · Cited by 939
Purification and Characterization of Tetrachloroethene Reductive Dehalogenase from
Neumann, A., Wohlfarth, G., & Diekert, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16515 · Cited by 182
Nagata, Y., Mori, K., Takagi, M., Murzin, A. G., & Damborský, J. (2001) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.10007 · Cited by 43
Halometabolites and Cellular Dehalogenase Systems: An Evolutionary Perspective
Valverde-R, C., Orozco, A., Becerra, A., Jeziorski, M. C., Villalobos, P., & Solís-S, J. C. (2004) · International Review of Cytology · doi:10.1016/s0074-7696(04)34004-0 · Cited by 28
Metadata
- Authors
- Janssen, D. B., Pries, F., & van der Ploeg, J. R.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1994-10
- Volume
- 48
- Issue
- 1
- Pages
- 163-191
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2107194519
- Cited by
- 198
- References
- 0
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: GENETICS AND BIOCHEMISTRY OF DEHALOGENATING ENZYMES. https://app.cochat.ai/papers/10.1146/annurev.mi.48.100194.001115
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- Janssen, D. B., Pries, F., & van der Ploeg, J. R. (1994). GENETICS AND BIOCHEMISTRY OF DEHALOGENATING ENZYMES. Annual Review of Microbiology. https://doi.org/10.1146/annurev.mi.48.100194.001115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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