The DOI matches its Crossref record; 82 of the 83 references it cites were found in a registry or an index.
MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
Abstract
Microbial adhesion to host tissue is the initial critical event in the pathogenesis of most infections and, as such, is an attractive target for the development of new antimicrobial therapeutics. Specific microbial components (adhesins) mediate adherence to host tissues by participating in amazingly sophisticated interactions with host molecules. This review focuses on a class of cell surface adhesins that specifically interact with extracellular matrix components and which we have designated MSCRAMMs (microbial surface components recognizing adhesive matrix molecules). MSCRAMMs recognizing fibronectin-, fibrinogen-, collagen-, and heparin-related polysaccharides are discussed in terms of structural organization, ligand-binding structures, importance in host tissue colonization and invasion, and role as virulence factors.
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“Some bacterial adhesins, for example surface proteins that interact with extracellular matrix molecules of their host (fibronectin, collagen, laminin, fibrinogen or others), have been classified as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs); full reviews of MSCRAMMs have been published elsewhere [4].”
From Protein sorting to the cell wall envelope of Gram-positive bacteria (2004) · cites this paper as [4]
Citations
Cites
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Fibronectin binds to Staphylococcus aureus
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Cited by
Sorted by citations
Staphylococcus aureus Infections
Lowy, F. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390806 · Cited by 6,018
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Zimmerli, W., Trampuž, A., & Ochsner, P. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040181 · Cited by 3,161
The role of nasal carriage in Staphylococcus aureus infections
Wertheim, H. F., Melles, D. C., Vos, M. C., van Leeuwen, W., van Belkum, A., Verbrugh, H. A., & Nouwen, J. L. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70295-4 · Cited by 2,685
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks
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Metadata
- Authors
- Patti, J. M., Allen, B. L., McGavin, M. J., & Höök, M.
- Affiliations
- Texas A&M University (US)
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1994-10
- Volume
- 48
- Issue
- 1
- Pages
- 585-617
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2176472482
- Cited by
- 1,191
- References
- 83
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 32 · 2023: 20 · 2022: 19 · 2021: 29 · 2020: 40 · 2019: 32 · 2018: 23 · 2017: 36 · 2016: 36 · 2015: 40 · 2014: 64 · 2013: 51 · 2012: 56
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl047313-03)
- National Heart, Lung, and Blood Institute (HL 47313)
- National Institute of Allergy and Infectious Diseases (AI20624)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- MSCRAMMs, microbial adhesion, extracellular matrix, adhesins, fibronectin, fibrinogen, collagen, heparin, ligand binding, virulence factors, host-pathogen interaction, antimicrobial agents
- MeSH terms
- Amino Acid Sequence, Bacterial Adhesion, Gram-Negative Bacteria, Gram-Positive Bacteria, Heparin, Molecular Sequence Data, Extracellular Matrix Proteins, Adhesins, Bacterial
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