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Biological Insights from Structures of Two-Component Proteins
Open accessAbstract
Two-component signal transduction based on phosphotransfer from a histidine protein kinase to a response regulator protein is a prevalent strategy for coupling environmental stimuli to adaptive responses in bacteria. In both histidine kinases and response regulators, modular domains with conserved structures and biochemical activities adopt different conformational states in the presence of stimuli or upon phosphorylation, enabling a diverse array of regulatory mechanisms based on inhibitory and/or activating protein-protein interactions imparted by different domain arrangements. This review summarizes some of the recent structural work that has provided insight into the functioning of bacterial histidine kinases and response regulators. Particular emphasis is placed on identifying features that are expected to be conserved among different two-component proteins from those that are expected to differ, with the goal of defining the extent to which knowledge of previously characterized two-component proteins can be applied to newly discovered systems.
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Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
The HAMP Domain Structure Implies Helix Rotation in Transmembrane Signaling
Hulko, M., Berndt, F., Gruber, M., Linder, J. U., Truffault, V., Schultz, A., Martin, J., Schultz, J. E., Lupas, A. N., & Coles, M. (2006) · Cell · doi:10.1016/j.cell.2006.06.058 · Cited by 416
Cited by
Evolution of Two-Component Signal Transduction Systems
Capra, E. J., & Laub, M. T. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150039 · Cited by 705
Molecular Mechanisms of Two-Component Signal Transduction
Zschiedrich, C. P., Keidel, V., & Szurmant, H. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.003 · Cited by 540
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Structural insights into the signalling mechanisms of two-component systems
Jacob-Dubuisson, F., Mechaly, A., Betton, J.-M., & Antoine, R. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0055-7 · Cited by 308
The mechanism of signal transduction by two-component systems
Casino, P., Rubio, V., & Marina, A. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.09.010 · Cited by 255
Metadata
- Authors
- Gao, R., & Stock, A. M.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2009-10-01
- Volume
- 63
- Issue
- 1
- Pages
- 133-154
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2125112034
- Cited by
- 792
- References
- 2
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Gao, R., & Stock, A. M. (2009). Biological Insights from Structures of Two-Component Proteins. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.091208.073214
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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