The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Mitochondrial Evolution and Functions in Malaria Parasites
Abstract
Mitochondria in malaria parasites have some unusual evolutionary and functional features. The drastic reduction in the size of their mitochondrial genome, encoding just three proteins, appears to have originated at the point of divergence of dinoflagellates and apicomplexan parasites from ciliates and may have accompanied the acquisition of plastids by the former. Unusual translational machinery as revealed by the highly fragmented mitochondrial ribosomal RNA genes also appears to have originated at this deflection point. Some of the biochemical properties of malarial mitochondria also appear to be unconventional. Although tricarboxylic acid cycle enzymes are encoded by the genome, they do not appear to be involved in the full oxidation of glucose to fuel mitochondrial ATP synthesis in the blood stages of malaria parasites. A critical role of the mitochondrial electron transport chain appears to be to serve pyrimidine biosynthesis. In spite of their minimal nature, Plasmodium mitochondria are attractive targets for antimalarial drugs.
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Cites
Genome sequence of the human malaria parasite Plasmodium falciparum
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Complete Gene Map of the Plastid-like DNA of the Malaria ParasitePlasmodium falciparum
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Cited by
Shared Signatures of Parasitism and Phylogenomics Unite Cryptomycota and Microsporidia
James, T. Y., Pelin, A., Bonen, L., Ahrendt, S., Sain, D., Corradi, N., & Stajich, J. E. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.057 · Cited by 349
Metadata
- Authors
- Vaidya, A. B., & Mather, M. W.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2009-10-01
- Volume
- 63
- Issue
- 1
- Pages
- 249-267
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2129539565
- Cited by
- 264
- References
- 87
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vaidya, A. B., & Mather, M. W. (2009). Mitochondrial Evolution and Functions in Malaria Parasites. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.091208.073424
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
