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Bacteriophage Therapy
Abstract
▪ Abstract In 1917, bacteriophages were recognized as epizootic infections of bacteria and were almost immediately deployed for antibacterial therapy and prophylaxis. The early trials of bacteriophage therapy for infectious diseases were confounded, however, because the biological nature of bacteriophage was poorly understood. The early literature reviewed here indicates that there are good reasons to believe that phage therapy can be effective in some circumstances. The advent of antibiotics, together with the “Soviet taint” acquired by phage therapy in the postwar period, resulted in the absence of rigorous evaluations of phage therapy until very recently. Recent laboratory and animal studies, exploiting current understandings of phage biology, suggest that phages may be useful as antibacterial agents in certain conditions.
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Cited by
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(U.S.), C. F. D. C. A. P. (2019) · doi:10.15620/cdc:82532 · Cited by 5,782
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Singer, M., Bulled, N., Ostrach, B., & Mendenhall, E. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30003-x · Cited by 1,491
Pros and cons of phage therapy
Loc-Carrillo, C., & Abedon, S. T. (2011) · Bacteriophage · doi:10.4161/bact.1.2.14590 · Cited by 1,020
Dispersing biofilms with engineered enzymatic bacteriophage
Lu, T. K., & Collins, J. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704624104 · Cited by 895
Topical Antimicrobials for Burn Wound Infections
Dai, T., Huang, Y.-Y., K. Sharma, S., T. Hashmi, J., B. Kurup, D., & R. Hamblin, M. (2010) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489110791233522 · Cited by 265
Metadata
- Authors
- Summers, W. C.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2001-10
- Volume
- 55
- Issue
- 1
- Pages
- 437-451
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W4231940808
- Cited by
- 474
- References
- 0
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
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