Evolution of Drug Resistance in Candida Albicans
Abstract
The widespread deployment of antimicrobial agents in medicine and agriculture is nearly always followed by the evolution of resistance to these agents in the pathogen. With the limited availability of antifungal drugs and the increasing incidence of opportunistic fungal infections, the emergence of drug resistance in fungal pathogens poses a serious public health concern. Antifungal drug resistance has been studied most extensively with the yeast Candida albicans owing to its importance as an opportunistic pathogen and its experimental tractability relative to other medically important fungal pathogens. The emergence of antifungal drug resistance is an evolutionary process that proceeds on temporal, spatial, and genomic scales. This process can be observed through epidemiological studies of patients and through population-genetic studies of pathogen populations. Population-genetic studies rely on sampling of the pathogen in patient populations, serial isolations of the pathogen from individual patients, or experimental evolution of the pathogen in nutrient media or in animal models. Predicting the evolution of drug resistance is fundamental to prolonging the efficacy of existing drugs and to strategically developing and deploying novel drugs.
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C. albicans infections are typically treated with azole inhibitors of ergosterol biosynthesis, often leading to drug resistance.
“Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance.”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Cowen et al., 2002
Several studies have shown a high consistency between results obtained in vivo and in vitro in yeasts like C. albicans and S. cerevisiae.
“Several studies have shown a high consistency between results obtained in vivo and in vitro in yeasts like C. albicans and S. cerevisiae [147,148].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [147]
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References 150 · Cited by 151
- Authors
- Cowen, L. E., Anderson, J. B., & Kohn, L. M.
- Affiliations
- University of Toronto (CA)
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2002-10
- Volume
- 56
- Issue
- 1
- Pages
- 139-165
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2150296897
- Cited by
- 151
- References
- 150
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 11
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida albicans, antifungal resistance, drug resistance evolution, opportunistic fungal infection, population genetics, experimental evolution, serial passage, epidemiology of resistance, resistance prediction, antifungal drug development
- MeSH terms
- Antifungal Agents, Candida albicans, Biological Evolution, Humans, Mutation, Mycoses, Genomics, Drug Resistance, Fungal
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