The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Mechanism of Isoniazid Killing: Clarity Through the Scope of Genetics
Abstract
Isoniazid (INH) is one of the most efficient drugs for the treatment of Mycobacterium tuberculosis infections. Despite its rather simple chemical structure, the mechanism by which INH kills M. tuberculosis is complex. A full understanding of the mechanisms of action of INH required the development of genetic tools in M. tuberculosis. Herein, we discuss the different hypotheses that have been used to describe INH action against M. tuberculosis over the past 50 years in terms of the pregenetic and genetic era. We also review the different mechanisms of INH resistance and propose what we think is the means by which INH kills M. tuberculosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis
Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K. S., Wilson, T., Collins, D., de Lisle, G., & Jacobs, W. R. (1994) · Science · doi:10.1126/science.8284673 · Cited by 1,389
Self-citationThe catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
Zhang, Y., Heym, B., Allen, B., Young, D., & Cole, S. (1992) · Nature · doi:10.1038/358591a0 · Cited by 1,299
Lysogeny and transformation in mycobacteria: stable expression of foreign genes.
Snapper, S. B., Lugosi, L., Jekkel, A., Melton, R. E., Kieser, T., Bloom, B. R., & Jacobs, W. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6987 · Cited by 326
Self-citationIntroduction of foreign DNA into mycobacteria using a shuttle phasmid
Jacobs, W. R., Tuckman, M., & Bloom, B. R. (1987) · Nature · doi:10.1038/327532a0 · Cited by 314
Self-citationAltered NADH/NAD + Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria
Vilchèze, C., Weisbrod, T. R., Chen, B., Kremer, L., Hazbón, M. H., Wang, F., Alland, D., Sacchettini, J. C., & Jacobs, W. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.708-720.2005 · Cited by 284
Self-citation
Cited by
Dynamic Persistence of Antibiotic-Stressed Mycobacteria
Wakamoto, Y., Dhar, N., Chait, R., Schneider, K., Signorino-Gelo, F., Leibler, S., & McKinney, J. D. (2013) · Science · doi:10.1126/science.1229858 · Cited by 542
Almeida Da Silva, P. E., & Palomino, J. C. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr173 · Cited by 532
Why do bacteria use so many enzymes to scavenge hydrogen peroxide?
Mishra, S., & Imlay, J. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.04.014 · Cited by 411
Dookie, N., Rambaran, S., Padayatchi, N., Mahomed, S., & Naidoo, K. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx506 · Cited by 346
The Granuloma in Tuberculosis: Dynamics of a Host–Pathogen Collusion
Ehlers, S., & Schaible, U. E. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00411 · Cited by 342
Metadata
- Authors
- Vilchèze, C., & Jacobs, Jr.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2007-10-01
- Volume
- 61
- Issue
- 1
- Pages
- 35-50
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2102428789
- Cited by
- 335
- References
- 5
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Mechanism of Isoniazid Killing: Clarity Through the Scope of Genetics. https://app.cochat.ai/papers/10.1146/annurev.micro.61.111606.122346
- The paper
- Vilchèze, C., & Jacobs, Jr. (2007). The Mechanism of Isoniazid Killing: Clarity Through the Scope of Genetics. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.61.111606.122346
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
