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MPTP Toxicity: Implications for Research in Parkinson's Disease
Abstract
In summary, the parkinsonism induced by MPTP in man closely resembles time-telescoped Parkinson's disease. Parkinsonian symptoms can be duplicated in all aspects under controlled conditions in subhuman primates; the biochemical changes are replicated in mice, dogs, and to varying degrees in other species. Mechanisms of bioactivation by MAO-B of MPTP to MPP+, concentration of MPP+ in neurons with a catecholamine uptake system, and vulnerability to cellular toxic effects of MPP+ are the basis for the specificity of MPTP targeting of nigrostriatal dopaminergic neurons. It is hoped that an understanding of the mechanism of species specificity and cellular toxicity will in time explain the pathogenesis of idiopathic Parkinson's disease and suggest new opportunities for effective therapy.
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Cited by
The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. R. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.507 · Cited by 1,365
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731
Przedborski, S., Jackson‐Lewis, V., Naini, A. B., Jakowec, M., Petzinger, G., Miller, R., & Akram, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00183.x · Cited by 507
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., Jarazo, J., Walter, J., Brüggemann, I., Boussaad, I., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.010 · Cited by 435
Metadata
- Authors
- Kopin, I. J., & Markey, S. P.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1988-03
- Volume
- 11
- Issue
- 1
- Pages
- 81-96
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2178105210
- Cited by
- 295
- References
- 0
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kopin, I. J., & Markey, S. P. (1988). MPTP Toxicity: Implications for Research in Parkinson's Disease. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.ne.11.030188.000501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
