The neurobiology of individual differences in complex behavioral traits
Open accessAbstract
Neuroimaging, especially BOLD fMRI, has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. In parallel, pharmacological fMRI and multimodal PET/fMRI are identifying how variability in molecular signaling pathways influences individual differences in brain function. Against this background, functional genetic polymorphisms are being utilized to understand the origins of variability in signaling pathways as well as to model efficiently how such emergent variability impacts behaviorally relevant brain function. This article provides an overview of a research strategy seeking to integrate these complementary technologies and utilizes existing empirical data to illustrate its effectiveness in illuminating the neurobiology of individual differences in complex behavioral traits. The article also discusses how such efforts can contribute to the identification of predictive markers that interact with environmental factors to precipitate disease and to develop more effective and individually tailored treatment regimes.
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The right amygdala plays a specific role in processing angry and fearful facial expressions.
“The finding of stronger reac vity in the right amygdala is in line with previous work showing stronger role of the right hemisphere in processing faces and sugges ons that the right amygdala plays a specific role in the processing of angry and fearful facial expressions [36, 55, 56].”
From Amygdala Reactivity, Antidepressant Discontinuation, and Relapse (2024) · cites this paper as [56]
The section “Trait Anxiety, the Amygdala, and Serotonin” reports amygdala responses to angry and fearful facial expressions. It does not identify a specific role for the right amygdala or establish a right-hemisphere advantage in face processing. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe right hemisphere has a stronger role in processing faces.
“The finding of stronger reac vity in the right amygdala is in line with previous work showing stronger role of the right hemisphere in processing faces and sugges ons that the right amygdala plays a specific role in the processing of angry and fearful facial expressions [36, 55, 56].”
From Amygdala Reactivity, Antidepressant Discontinuation, and Relapse (2024) · cites this paper as [56]
The section “Trait Anxiety, the Amygdala, and Serotonin” says the amygdala responds to emotional facial expressions, but it does not compare the right and left hemispheres. Searches for right-hemisphere face processing and amygdala lateralization found no passage establishing a stronger role for the right hemisphere; page numbers were unavailable in our copy. (LLM, conf=0.73)
Experimental — accuracy not yet measuredStructural and functional brain indices may be sufficiently stable within and across developmental periods to warrant treatment as susceptibility factors.
“Finally, structural and functional brain indices may be sufficiently stable within and across developmental periods (Caceres et al., 2009, Forbes et al., 2009, Hariri, 2009, Johnstone et al., 2005, Manuck et al., 2007, Miller et al., 2002, Miller et al., 2009, Wu et al., 2014, Zuo et al., 2010) to warrant treatment as susceptibility factors.”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Hariri, 2009
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References 122 · Cited by 273
- Authors
- Hariri, A. R.
- Affiliations
- Duke University (US)
- Corresponding author
- Hariri, Ahmad R.
- ORCID
- Hariri, Ahmad R.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 32
- Issue
- 1
- Pages
- 225-247
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC2755193
- OpenAlex
- W2110601854
- Cited by
- 273
- References
- 122
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 49 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 19 · 2014: 16 · 2013: 24 · 2012: 37
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01MH072837)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- individual differences, pharmacological fMRI, molecular pathways, predictive biomarkers, personalized treatment, neurobiology of behavior
- MeSH terms
- Animals, Behavior, Brain Mapping, Humans, Magnetic Resonance Imaging, Neuropsychology, Genetic Variation, Biomarkers, Quantitative Trait, Heritable, Genetic Predisposition to Disease, Positron-Emission Tomography
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