The DOI matches its Crossref record.
Regulation of the Pyruvate Dehydrogenase Multienzyme Complex
Abstract
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
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“The PDHC is allosterically inhibited by NADH, acetyl-CoA, and ATP, making it a potent sensor of TCA cycle activity and thus a critical node of TCA cycle regulation (discussed further) (52).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [52]
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Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 719
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling
Færgeman, N. J., & Knudsen, J. (1997) · Biochemical Journal · doi:10.1042/bj3230001 · Cited by 681
Sutendra, G., Kinnaird, A. S., Dromparis, P., Paulin, R., Stenson, T. H., Haromy, A., Hashimoto, K., Zhang, N., Flaim, E., & Michelakis, E. D. (2014) · Cell · doi:10.1016/j.cell.2014.04.046 · Cited by 633
Alterations in carbohydrate metabolism during stress: A review of the literature
Mizock, B. A. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80083-7 · Cited by 534
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535
“The PDHC is allosterically inhibited by NADH, acetyl-CoA, and ATP, making it a potent sensor of TCA cycle activity and thus a critical node of TCA cycle regulation (discussed further) (52).”
Background
Metadata
- Authors
- Behal, R. H., Buxton, D. B., Robertson, J. G., & Olson, M. S.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1993-07
- Volume
- 13
- Issue
- 1
- Pages
- 497-520
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2173424827
- Cited by
- 132
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 3 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl024654-10)
- National Heart, Lung, and Blood Institute (HL-24654)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- pyruvate dehydrogenase complex, enzyme regulation, intermittent fasting, health benefits of fasting, physiological mechanisms, metabolic regulation
- MeSH terms
- Animals, Catalysis, Homeostasis, Hormones, Humans, Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase Complex Deficiency Disease
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