The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation
Open accessAbstract
▪ Abstract The amino acid response (AAR) pathway in mammalian cells is designed to detect and respond to amino acid deficiency. Limiting any essential amino acid initiates this signaling cascade, which leads to increased translation of a “master regulator,” activating transcription factor (ATF) 4, and ultimately, to regulation of many steps along the pathway of DNA to RNA to protein. These regulated events include chromatin remodeling, RNA splicing, nuclear RNA export, mRNA stabilization, and translational control. Proteins that are increased in their expression as targets of the AAR pathway include membrane transporters, transcription factors from the basic region/leucine zipper (bZIP) superfamily, growth factors, and metabolic enzymes. Significant progress has been achieved in understanding the molecular mechanisms by which amino acids control the synthesis and turnover of mRNA and protein. Beyond gaining additional knowledge of these important regulatory pathways, further characterization of how these processes contribute to the pathology of various disease states represents an interesting aspect of future research in molecular nutrition.
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Cited by
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Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism
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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
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Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions
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Metadata
- Authors
- Kilberg, M. S., Pan, Y.-X., Chen, H., & Leung-Pineda, V.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2005-08-21
- Volume
- 25
- Issue
- 1
- Pages
- 59-85
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2128600167
- Cited by
- 288
- References
- 114
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Kilberg, M. S., Pan, Y.-X., Chen, H., & Leung-Pineda, V. (2005). NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.24.012003.132145
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