The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pathobiology of Pulmonary Hypertension
Abstract
A variety of conditions can lead to the development of pulmonary arterial hypertension (PAH). Current treatments can improve symptoms and reduce the severity of the hemodynamic abnormality, but most patients remain quite limited, and deterioration in their condition necessitates a lung transplant. This review discusses current experimental and clinical studies that investigate the pathobiology of PAH. An emerging theme is the consideration of ways in which one might reverse the advanced occlusive structural changes in the pulmonary circulation causing PAH. The current debate concerning the role of regeneration through stem cells is presented. This review also highlights investigations in a number of laboratories relating the pathobiology of PAH to mutations causing loss of function of bone morphogenetic protein receptor II in patients with familial PAH, as well as sporadic cases.
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Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
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Appetite-suppressant drugs and the risk of primary pulmonary hypertension
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KANEKO, F. T., ARROLIGA, A. C., DWEIK, R. A., COMHAIR, S. A., LASKOWSKI, D., OPPEDISANO, R., THOMASSEN, M. J., & ERZURUM, S. C. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.3.9802066 · Cited by 228
Pulmonary hypertension and inflammation
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Cited by
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,066
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.001 · Cited by 1,533
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Mechanisms of disease: pulmonary arterial hypertension
Schermuly, R. T., Ghofrani, H. A., Wilkins, M. R., & Grimminger, F. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.87 · Cited by 800
Stenmark, K. R., Meyrick, B., Galie, N., Mooi, W. J., & McMurtry, I. F. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00217.2009 · Cited by 774
Metadata
- Authors
- Rabinovitch, M.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2007-02-01
- Volume
- 2
- Issue
- 1
- Pages
- 369-399
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2147011107
- Cited by
- 301
- References
- 5
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rabinovitch, M. (2007). Pathobiology of Pulmonary Hypertension. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev.pathol.2.010506.092033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
