The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Regulation of Aldosterone Secretion
Abstract
Regulation of aldosterone secretion is complex both in terms of the number of secretagogues that can influence its biosynthesis and the number of second messengers utilized by these secretagogues (Table 1, Figure 1). ACTH primarily acts via the adenylate cyclase system through a stimulatory G protein; however, there is evidence that at low concentration it may also activate calcium influx and phospholipase C in some species. The primary effect of AII is activation of phospholipase C, which increases both calcium release from intracellular stores and calcium flux across the cell membrane and activates protein kinase C. Potassium depolarizes the membrane, thereby activating calcium flow through voltage-dependent calcium channels. It also directly or indirectly causes release of calcium from intracellular binding sites. A small change in cAMP levels may also be involved in the sustained secretory response to potassium. Species variation in the regulation of aldosterone secretion probably exists; the control mechanisms in the human appear to be closer to those in the rat than to those in cow and sheep. How changes in dietary sodium and potassium modify aldosterone secretion and the adrenal's responsiveness to secretagogues remains unclear. Yet these effects may be of considerable importance, both in terms of understanding the overall regulation of aldosterone secretion and in resolving the discrepancies in the results obtained under different experimental conditions.
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Ames, R. P., Borkowski, A. J., Sicinski, A. M., & Laragh, J. H. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105224 · Cited by 341
Hollenberg, N. K., Chenitz, W. R., Adams, D. F., & Williams, G. H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107748 · Cited by 333
Self-citationRole of Potassium in the Control of Aldosterone Secretion in the Rat
BOYD, J. E., Palmore, W. P., & Mulrow, P. J. (1971) · Endocrinology · doi:10.1210/endo-88-3-556 · Cited by 108
Electrical Properties of Isolated Rat Adrenal Glomerulosa and Fasciculata Cells*
QUINN, S. J., Cornwall, M. C., & Williams, G. H. (1987) · Endocrinology · doi:10.1210/endo-120-3-903 · Cited by 91
Self-citationBalla, T., Baukal, A. J., Guillemette, G., Morgan, R. O., & Catt, K. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9323 · Cited by 83
Electrophysiological Responses to Angiotensin II of Isolated Rat Adrenal Glomerulosa Cells*
QUINN, S. J., Cornwall, M. C., & Williams, G. H. (1987) · Endocrinology · doi:10.1210/endo-120-4-1581 · Cited by 77
Self-citationDoi, Y., Atarashi, K., Franco-Saenz, R., & Mulrow, P. J. (1984) · Hypertension · doi:10.1161/01.hyp.6.2_pt_2.i124 · Cited by 75
Braley, L. M., MENACHERY, A. I., Brown, E. M., & Williams, G. H. (1986) · Endocrinology · doi:10.1210/endo-119-3-1010 · Cited by 66
Self-citationNaruse, M., Obana, K., Naruse, K., YAMAGUCHI, H., Demura, H., Inagami, T., & SHIZUME, K. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-10 · Cited by 60
Balla, T., Enyedi, P., Spät, A., & Antoni, F. A. (1985) · Endocrinology · doi:10.1210/endo-117-1-421 · Cited by 57
Cited by
Physiology of Local Renin-Angiotensin Systems
Paul, M., Poyan Mehr, A., & Kreutz, R. (2006) · Physiological Reviews · doi:10.1152/physrev.00036.2005 · Cited by 1,739
Renin–angiotensin–aldosterone system blockade for cardiovascular diseases: current status
Ma, T. K., Kam, K. K., Yan, B. P., & Lam, Y. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00750.x · Cited by 364
Role of Aldosterone in Renal Vascular Injury in Stroke-Prone Hypertensive Rats
Rocha, R., Chander, P. N., Zuckerman, A., & Stier, C. T. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.232 · Cited by 310
Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
Goodfriend, T. L., & Calhoun, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000116223.97436.e5 · Cited by 279
Angiotensin II and Potassium Regulate Human CYP11B2 Transcription through Common cis-Elements
Clyne, C. D., Zhang, Y., Slutsker, L., Mathis, J. M., White, P. C., & Rainey, W. E. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.5.9920 · Cited by 202
Metadata
- Authors
- Quinn, S. J., & Williams, G. H.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1988-10
- Volume
- 50
- Issue
- 1
- Pages
- 409-426
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2102519244
- Cited by
- 313
- References
- 16
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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