The DOI matches its Crossref record.
Low-Threshold Calcium Currents in Central Nervous System Neurons
Abstract
The low-threshold calcium current, or T current, has recently been demonstrated with voltage-clamp recordings in a variety of central nervous system (CNS) neurons. It is especially prominent in the soma and dendrites of neurons with robust calcium-dependent burst firing behaviors such as thalamic relay neurons and cerebellar Purkinje cells. Single-channel and macroscopic current behavior have been carefully investigated and kinetic schemes devised to completely describe the activation and inactivation processes. The kinetic properties of T current lead to activation of low-threshold spikes subsequent to transient membrane hyperpolarizations. Putative functional roles for T current include generation of low-threshold spikes that lead to burst firing, promotion of intrinsic oscillatory behavior, boosting of calcium entry, and synaptic potentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296
Formation of Dendritic Spines with GABAergic Synapses Induced by Whisker Stimulation in Adult Mice
Knott, G. W., Quairiaux, C., Genoud, C., & Welker, E. (2002) · Neuron · doi:10.1016/s0896-6273(02)00663-3 · Cited by 438
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435
The reticular nucleus revisited: Intrinsic and network properties of a thalamic pacemaker
FUENTEALBA, P., & STERIADE, M. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.01.002 · Cited by 263
Zikopoulos, B., & Barbas, H. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.6.417 · Cited by 156
Metadata
- Authors
- Huguenard, J. R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1996-10
- Volume
- 58
- Issue
- 1
- Pages
- 329-348
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2178459653
- Cited by
- 763
- References
- 0
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Low-Threshold Calcium Currents in Central Nervous System Neurons. https://app.cochat.ai/papers/10.1146/annurev.ph.58.030196.001553
- The paper
- Huguenard, J. R. (1996). Low-Threshold Calcium Currents in Central Nervous System Neurons. Annual Review of Physiology. https://doi.org/10.1146/annurev.ph.58.030196.001553
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
