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ROLE OF ORGANIC CATION TRANSPORTERS IN DRUG ABSORPTION AND ELIMINATION
Abstract
▪ Abstract Organic cation transporters are critical in drug absorption, targeting, and disposition. It has become increasingly clear that multiple mechanisms are involved in organic cation transport in the key tissues responsible for drug absorption and disposition: the kidney, liver, and intestine. In this review, we discuss current models of transepithelial flux of organic cations in these three tissues. Particular emphasis is placed on the more recent molecular studies that have paved the way for a more complete understanding of the physiological and pharmacological roles of the organic cation transporters. Such information is essential in predicting pharmacokinetics and pharmacodynamics and in the design and development of cationic drugs.
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Citations
Cited by
Impact of Drug Transporter Studies on Drug Discovery and Development
Mizuno, N., Niwa, T., Yotsumoto, Y., & Sugiyama, Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.1 · Cited by 490
Yabuuchi, H., Tamai, I., Nezu, J.-I., Sakamoto, K., Oku, A., Shimane, M., Sai, Y., & Tsuji, A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38199-6 · Cited by 316
Shu, Y., Leabman, M. K., Feng, B., Mangravite, L. M., Huang, C. C., Stryke, D., Kawamoto, M., Johns, S. J., DeYoung, J., Carlson, E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730858100 · Cited by 285
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Metadata
- Authors
- Zhang, L., Brett, C. M., & Giacomini, K. M.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1998-04
- Volume
- 38
- Issue
- 1
- Pages
- 431-460
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2100713850
- Cited by
- 202
- References
- 0
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ROLE OF ORGANIC CATION TRANSPORTERS IN DRUG ABSORPTION AND ELIMINATION. https://app.cochat.ai/papers/10.1146/annurev.pharmtox.38.1.431
- The paper
- Zhang, L., Brett, C. M., & Giacomini, K. M. (1998). ROLE OF ORGANIC CATION TRANSPORTERS IN DRUG ABSORPTION AND ELIMINATION. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.38.1.431
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
