The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Teratology of Retinoids
Abstract
Either an excess or a deficiency of vitamin A and related compounds (retinoids) causes abnormal morphological development (teratogenesis). Potential retinoid sources come from dietary intake, nutritional supplements, and some therapeutic drugs. Therefore, understanding the mechanisms of retinoid teratogenesis is important. This review first gives an overview of the principles of teratology as they apply to retinoid-induced malformations. It then describes relevant aspects of the biochemical pathway and signal transduction of retinoids. The teratogenic activity of various retinoid compounds, the role of the retinoid receptors, and important toxicokinetic parameters in teratogenesis are reviewed.
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Cites
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Cited by
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The acute and chronic toxic effects of vitamin A
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T HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT
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“However, too much RA at critical stages can result in embryo lethality or malformation [117–120].”
BackgroundDiseases Caused by Defects in the Visual Cycle: Retinoids as Potential Therapeutic Agents
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Metadata
- Authors
- Collins, M. D., & Mao, G. E.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 39
- Issue
- 1
- Pages
- 399-430
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2123363472
- Cited by
- 288
- References
- 168
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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