The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Central Role of Peroxisome Proliferator–Activated Receptors in the Actions of Peroxisome Proliferators
Abstract
Peroxisome proliferators (PPs) are a large class of structurally dissimilar chemicals that have diverse effects in rodents and humans. Most, if not all, of the diverse effects of PPs are mediated by three members of the nuclear receptor superfamily called peroxisome proliferator-activated receptors (PPARs). In this review, we define the molecular mechanisms of PPs, including PPAR binding specificity, alteration of gene expression through binding to DNA response elements, and cross talk with other signaling pathways. We discuss the roles of PPARs in growth promotion in rodent hepatocarcinogenesis and potential therapeutic effects, including suppression of cancer growth and inflammation.
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Cites
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Cited by
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
The PPARα-Dependent Rodent Liver Tumor Response Is Not Relevant to Humans: Addressing Misconceptions
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Metadata
- Authors
- Corton, J. C., Anderson, S. P., & Stauber, A.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 40
- Issue
- 1
- Pages
- 491-518
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2126644867
- Cited by
- 341
- References
- 10
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Corton, J. C., Anderson, S. P., & Stauber, A. (2000). Central Role of Peroxisome Proliferator–Activated Receptors in the Actions of Peroxisome Proliferators. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.40.1.491
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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