The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antisense Oligonucleotides: Promise and Reality
Abstract
Antisense oligonucleotides have been used for more than a decade to downregulate gene expression. Phosphodiester oligonucleotides are nuclease sensitive, and the more nuclease-resistant phosphorothioate oligonucleotides are now in common use in the laboratory and have entered clinical trials. However, these molecules are highly bioactive and may inhibit gene expression by more than one mechanism. Although some dramatic successes have been demonstrated, it can still be difficult to properly interpret experimental data derived from the use of this class of oligonucleotide. This review discusses some of these issues with particular reference to a major area of current interest—inhibition of bcl-2 expression in tumor cells.
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Cites
Tetranucleotide GGGA Motif in Primary RNA Transcripts
Tu, G.-C., Cao, Q.-N., Zhou, F., & Israel, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25125 · Cited by 93
Cited by
siRNA-based approaches in cancer therapy
Devi, G. R. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700931 · Cited by 353
Réjiba, S., Wack, S., Aprahamian, M., & Hajri, A. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00506.x · Cited by 89
Metadata
- Authors
- Lebedeva, I., & Stein, C.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 41
- Issue
- 1
- Pages
- 403-419
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W1942185956
- Cited by
- 236
- References
- 1
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
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