The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Endothelin System: The Double-Edged Sword in Health and Disease
Abstract
The endothelin system consists of two G-protein-coupled receptors, three peptide ligands, and two activating peptidases. Its pharmacological complexity is reflected by the diverse expression pattern of endothelin system components, which have a variety of physiological and pathophysiological roles. In the vessels, the endothelin system has a basal vasoconstricting role and participates in the development of diseases such as hypertension, atherosclerosis, and vasospasm after subarachnoid hemorrhage. In the heart, the endothelin system affects inotropy and chronotropy, and it mediates cardiac hypertrophy and remodeling in congestive heart failure. In the lungs, the endothelin system regulates the tone of airways and blood vessels, and it is involved in the development of pulmonary hypertension. In the kidney, it controls water and sodium excretion and acid-base balance, and it participates in acute and chronic renal failure. In the brain, the endothelin system modulates cardiorespiratory centers and the release of hormones. More advanced functional analysis of the endothelin system awaits not only additional pharmacological studies using highly specific endothelin antagonists but also the generation of genetically altered rodent models with conditional loss-of-function and gain-of-function manipulations.
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Cites
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,729
Self-citationCloning and expression of a cDNA encoding an endothelin receptor
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Self-citationCloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
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Self-citationExpression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension
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Self-citationRelease of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.
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Self-citationElevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
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Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?
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Cited by
Vascular Endothelial Cell Biology: An Update
Krüger-Genge, A., Blocki, A., Franke, R.-P., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,163
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Michiels, C. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10333 · Cited by 773
Endothelial Dysfunction and Hypertension
Konukoglu, D., & Uzun, H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_90 · Cited by 594
Schrijvers, B. F., De Vriese, A. S., & Flyvbjerg, A. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0018 · Cited by 353
Metadata
- Authors
- Kedzierski, R. M., & Yanagisawa, M.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 41
- Issue
- 1
- Pages
- 851-876
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W1972509561
- Cited by
- 745
- References
- 95
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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