The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
PROTEIN CRYSTALLIZATION
Abstract
▪ Abstract Crystallization is necessary to obtain the three-dimensional structure of proteins and nucleic acids; it often represents the bottleneck in structure determination. Our understanding of crystallization mechanisms is still incomplete. In this review, we emphasize fundamental aspects of the crystallization process. Protein-protein contacts in crystals are complex, involving a delicate balance of specific and nonspecific interactions. Depending on solution conditions, these interactions can lead to nucleation of crystals or to amorphous aggregation; this stage of crystallization has been successfully studied by light scattering. Post nucleation crystal growth may proceed by mechanisms involving crystal defects or two-dimensional nucleation, as observed by atomic force and interference microscopy. Cessation of growth has been observed but remains incompletely understood. Impurities may play important roles during all stages of crystallization. Phase diagrams can guide optimization of conditions for nucleation and subsequent crystal growth; a theoretical understanding relating these to the intermolecular interactions is beginning to develop.
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Cites
Funnels, pathways, and the energy landscape of protein folding: A synthesis
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340210302 · Cited by 2,648
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts
Lawson, D. M., Artymiuk, P. J., Yewdall, S. J., Smith, J. M. A., Livingstone, J. C., Treffry, A., Luzzago, A., Levi, S., Arosio, P., Cesareni, G., et al. (1991) · Nature · doi:10.1038/349541a0 · Cited by 777
Cited by
Liquid-Liquid Phase Separation in Biology
Hyman, A. A., Weber, C. A., & Jülicher, F. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013325 · Cited by 3,155
Metadata
- Authors
- Durbin, S. D., & Feher, G.
- Venue
- Annual Review of Physical Chemistry
- Publisher
- Annual Reviews
- Published
- 1996-10
- Volume
- 47
- Issue
- 1
- Pages
- 171-204
- ISSN
- 0066-426X (ISSN-L)
- 1545-1593
- OpenAlex
- W4236190433
- Cited by
- 303
- References
- 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Durbin, S. D., & Feher, G. (1996). PROTEIN CRYSTALLIZATION. Annual Review of Physical Chemistry. https://doi.org/10.1146/annurev.physchem.47.1.171
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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