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“STRONG” HYDROGEN BONDS IN CHEMISTRY AND BIOLOGY
Abstract
▪ Abstract Hydrogen bonds are a key feature of chemical structure and reactivity. Recently there has been much interest in a special class of hydrogen bonds called “strong” or “low-barrier” and characterized by great strength, short distances, a low or vanishing barrier to hydrogen transfer, and distinctive features in the NMR spectrum. Although the energy of an ordinary hydrogen bond is ca 5 kcal mol−1, the strength of these hydrogen bonds may be ≥10 kcal mol−1. The properties of these hydrogen bonds have been investigated by many experimental techniques, as well as by calculation and by correlations among those properties. Although it has been proposed that strong, short, low-barrier hydrogen bonds are important in enzymatic reactions, it is concluded that the evidence for them in small molecules and in biomolecules is inconclusive.
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Cited by
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Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
cAMP Analog Mapping of Epac1 and cAMP Kinase
Christensen, A. E., Selheim, F., de Rooij, J., Dremier, S., Schwede, F., Dao, K. K., Martinez, A., Maenhaut, C., Bos, J. L., Genieser, H.-G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302179200 · Cited by 396
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Metadata
- Authors
- Perrin, C. L., & Nielson, J. B.
- Venue
- Annual Review of Physical Chemistry
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 48
- Issue
- 1
- Pages
- 511-544
- ISSN
- 0066-426X (ISSN-L)
- 1545-1593
- OpenAlex
- W2063661958
- Cited by
- 829
- References
- 0
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perrin, C. L., & Nielson, J. B. (1997). “STRONG” HYDROGEN BONDS IN CHEMISTRY AND BIOLOGY. Annual Review of Physical Chemistry. https://doi.org/10.1146/annurev.physchem.48.1.511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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