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THE CHLORIDE CELL:Structure and Function in the Gills of Freshwater Fishes
Abstract
▪ Abstract This review focuses on the structure and function of the branchial chloride cell in freshwater fishes. The mitochondria-rich chloride cell is believed to be the principal site of trans-epithelial Ca 2+and Cl−influxes. Though currently debated, there is accruing evidence that the pavement cell is the site of Na+uptake via channels linked electrically to an apical membrane vacuolar H+-ATPase (proton pump). Chloride cells perform an integral role in acid-base regulation. During conditions of alkalosis, the surface area of exposed chloride cells is increased, which serves to enhance base equivalent excretion as the rate of Cl−/HCO 3−exchange is increased. Conversely, during acidosis, the chloride cell surface area is diminished by an expansion of the adjacent pavement cells. This response reduces the number of functional Cl−/HCO 3−exchangers. Under certain conditions that challenge ion regulation, chloride cells proliferate on the lamellae. This response, while optimizing the Ca 2+and Cl−transport capacity of the gill, causes a thickening of the blood-to-water diffusion barrier and thus impedes respiratory gas transfer.
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Citations
Cited by
Ontogeny of osmoregulation in postembryonic fish: A review
Varsamos, S., Nebel, C., & Charmantier, G. (2005) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.01.013 · Cited by 417
LeBlanc, D. M., Wood, C. M., Fudge, D. S., & Wright, P. A. (2010) · Physiological and Biochemical Zoology · doi:10.1086/656307 · Cited by 72
Histopathological Effects in Fish Exposed to the Toxins from Karlodinium micrum
Deeds, J. R., Reimschuessel, R., & Place, A. R. (2006) · Journal of Aquatic Animal Health · doi:10.1577/h05-027.1 · Cited by 72
Wilkie, M. P., Morgan, T. P., Galvez, F., Smith, R. W., Kajimura, M., Ip, Y. K., & Wood, C. M. (2007) · Physiological and Biochemical Zoology · doi:10.1086/508837 · Cited by 59
Mitochondria-rich cells in gills and skin of an African lungfish, Protopterus annectens
Sturla, M., Masini, M. A., Prato, P., Grattarola, C., & Uva, B. (2001) · Cell and Tissue Research · doi:10.1007/s004410000341 · Cited by 54
Metadata
- Authors
- Perry, S. F.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 59
- Issue
- 1
- Pages
- 325-347
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2170717256
- Cited by
- 551
- References
- 0
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perry, S. F. (1997). THE CHLORIDE CELL:Structure and Function in the Gills of Freshwater Fishes. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.59.1.325
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
