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THE PULMONARY LIPOFIBROBLAST (LIPID INTERSTITIAL CELL) AND ITS CONTRIBUTIONS TO ALVEOLAR DEVELOPMENT
Abstract
▪ Abstract The pulmonary lipofibroblast is located in the alveolar interstitium and is recognizable by its characteristic lipid droplets. During alveolar development it participates in the synthesis of extracellular matrix structural proteins, such as collagen and elastin, and as an accessory cell to the type II pneumocyte, in the synthesis of surfactant. The lipofibroblast contains cortical contractile filaments and is thereby related to the contractile interstitial cells that are normally found at the alveolar septal tips and after lung injury. The morphologic, immunologic, and biochemical characteristics of the lipofibroblast and its probable physiologic functions are reviewed. The retinoid and lipid metabolism of the lipofibroblast is compared with that of the hepatic lipocyte and the adipocyte. Although the functions of the lipofibroblast remain incompletely characterized, this cell type is emerging as an important contributor to pulmonary alveolar septal development.
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Cited by
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241
Type 2 alveolar cells are stem cells in adult lung
Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776
Brasaemle, D. L. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 992
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis
Xie, T., Wang, Y., Deng, N., Huang, G., Taghavifar, F., Geng, Y., Liu, N., Kulur, V., Yao, C., Chen, P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.010 · Cited by 527
Elastin in lung development and disease pathogenesis
Mecham, R. P. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.005 · Cited by 208
Metadata
- Authors
- McGowan, S. E., & Torday, J. S.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 59
- Issue
- 1
- Pages
- 43-62
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2157727603
- Cited by
- 213
- References
- 0
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE PULMONARY LIPOFIBROBLAST (LIPID INTERSTITIAL CELL) AND ITS CONTRIBUTIONS TO ALVEOLAR DEVELOPMENT. https://app.cochat.ai/papers/10.1146/annurev.physiol.59.1.43
- The paper
- McGowan, S. E., & Torday, J. S. (1997). THE PULMONARY LIPOFIBROBLAST (LIPID INTERSTITIAL CELL) AND ITS CONTRIBUTIONS TO ALVEOLAR DEVELOPMENT. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.59.1.43
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
