The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
CELL CYCLE REGULATION AND APOPTOSIS
Abstract
▪ Abstract Tissue homeostasis requires a balance between cell proliferation and death. Apoptosis and proliferation are linked by cell cycle regulators, and apoptotic stimuli affect both cell proliferation and death. Glucocorticoids induce G1 arrest and apoptosis in transformed lymphoid cells. Decreased expression of the cell cycle components c-myc and cyclin D3 is essential for glucocorticoid-induced growth arrest and death in dividing cells. Other G1 regulators, such as p53, pRb, and E2F, have also been implicated in apoptosis. Mice lacking either p53 or E2F display aberrant cell proliferation and tumor formation, suggesting that these proteins are involved in the elimination of abnormal cells through apoptosis. In contrast, pRb induces G1 arrest and suppresses apoptosis in cultured cells. Mice that lack pRb are nonviable and show ectopic mitosis and massive cell death, suggesting that pRb is an apoptotic suppressor. Further analysis of common components of apoptotic and cell cycle machinery may provide insight into the coordinated regulation of these antagonistic processes.
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WAF1, a potential mediator of p53 tumor suppression
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The retinoblastoma protein and cell cycle control
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Induction of apoptosis in fibroblasts by c-myc protein
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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Bcl-2 and the regulation of programmed cell death
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Thymocyte apoptosis induced by p53-dependent and independent pathways
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Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
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Cited by
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Apoptosis and Molecular Targeting Therapy in Cancer
Hassan, M., Watari, H., AbuAlmaaty, A., Ohba, Y., & Sakuragi, N. (2014) · BioMed Research International · doi:10.1155/2014/150845 · Cited by 1,121
RetractedNeuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Apoptosis and apoptotic body: disease message and therapeutic target potentials
Xu, X., Lai, Y., & Hua, Z.-C. (2019) · Bioscience Reports · doi:10.1042/bsr20180992 · Cited by 909
Zinc as a Gatekeeper of Immune Function
Wessels, I., Maywald, M., & Rink, L. (2017) · Nutrients · doi:10.3390/nu9121286 · Cited by 747
Metadata
- Authors
- King, K. L., & Cidlowski, J. A.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1998-10
- Volume
- 60
- Issue
- 1
- Pages
- 601-617
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2143938651
- Cited by
- 531
- References
- 90
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- King, K. L., & Cidlowski, J. A. (1998). CELL CYCLE REGULATION AND APOPTOSIS. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.60.1.601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
