Cited by 337Pancreatic and Hepatic Oncology ResearchMRI in cancer diagnosisPancreatitis Pathology and Treatment

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Isoattenuating Pancreatic Adenocarcinoma at Multi–Detector Row CT: Secondary Signs

Prokesch, Rupert W., Chow, Lawrence C., Beaulieu, Christopher F., Bammer, Roland, Jeffrey, R. Brooke·2002·Radiology

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Abstract

Purpose To assess the frequency of isoattenuating pancreatic adenocarcinoma with multi-detector row computed tomography (CT) and determine whether there are specific secondary signs that aid in detection. Materials and methods Fifty-three patients with pancreatic adenocarcinoma underwent contrast material-enhanced biphasic multi-detector row CT with curved planar reformation. Tumors were initially deemed isoattenuating or hypoattenuating to normal pancreatic parenchyma on the basis of visual inspection, and the degree of attenuation was confirmed by calculating the mean attenuation differences between normal pancreatic parenchyma and tumor (tumor-pancreas contrast) during the pancreatic phase. Indirect signs of pancreatic tumor were tabulated in patients with an isoattenuating tumor. Results Of the 53 patients, six (11%) had isoattenuating tumors with a mean tumor-pancreas contrast of 9.25 HU +/- 11.3 during the pancreatic phase and 4.15 HU +/- 8.5 during the portal venous phase. The secondary signs of pancreatic tumor in these six patients included an interrupted pancreatic duct (n = 5), dilated biliary and pancreatic ducts (n = 1), atrophic distal pancreatic parenchyma (n = 3), and mass effect and/or convex contour abnormality (n = 3). The mean tumor-pancreas contrast for the remaining 47 patients was 74.76 HU +/- 35.61 during the pancreatic phase. Conclusion With no visible tumor-pancreas contrast for isoattenuating tumors, indirect signs such as mass effect, atrophic dist…

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Authors: Prokesch, R. W., Chow, L. C., Beaulieu, C. F., Bammer, R., & Jeffrey, R. B.
Affiliations: Stanford Medicine (US)
ORCID: Beaulieu, Christopher F.
Bammer, Roland
Jeffrey, R. Brooke
Venue: Radiology
Publisher: Radiological Society of North America (RSNA)
Published: 2002-09
Volume: 224
Issue: 3
Pages: 764-768
ISSN: 0033-8419 (ISSN-L)
1527-1315
DOI: 10.1148/radiol.2243011284
OpenAlex: W2097793074
Cited by: 337
References: 15
Citations by year: 2026: 9 · 2025: 6 · 2024: 12 · 2023: 19 · 2022: 21 · 2021: 19 · 2020: 15 · 2019: 15 · 2018: 17 · 2017: 11 · 2016: 13 · 2015: 25 · 2014: 18 · 2013: 20 · 2012: 19
FWCI: 1.91
Type: journal article
Language: en
Open access: closed
Locations: Radiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic ductal adenocarcinoma, mass effect, tumor detection, multi-detector row CT, contrast-enhanced CT
MeSH terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Tomography, X-Ray Computed

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Isoattenuating Pancreatic Adenocarcinoma at Multi–Detector Row CT: Secondary Signs

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