The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Hepatocellular Carcinoma: Regional Therapy with a Magnetic Targeted Carrier Bound to Doxorubicin in a Dual MR Imaging/ Conventional Angiography Suite—Initial Experience with Four Patients
Abstract
Four patients with inoperable hepatocellular carcinoma were treated with a magnetic targeted carrier bound to doxorubicin (MTC-DOX) by using a joint magnetic resonance (MR) imaging/conventional angiography system consisting of a 1.5-T short-bore magnet connected to a C-arm angiography unit by a sliding tabletop. Selective transcatheter delivery of the MTC-DOX to the hepatic artery was monitored by using intraprocedural MR imaging, and interim catheter manipulation was performed with fluoroscopic guidance to optimize agent delivery to the tumor and minimize delivery to normal tissue. The final fraction of treated tumor volume ranged from 0.64 to 0.91. The fraction of affected normal liver volume ranged from 0.07 to 0.30. The dual MR imaging/conventional angiography system shows promise for directing magnetically targeted tumor therapies.
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“From a translational point of view, only one magnetically targeted nanocarrier (which was loaded with doxorubicin; MTC-DOX) has been evaluated in patients, but it did not produce convincing results, leading to termination of clinical development in phase II/III [232, 233].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [232]
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Cites
MR Imaging-guided Percutaneous Cryotherapy of Liver Tumors: Initial Experience
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Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC)
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Small hepatocellular carcinoma treated with percutaneous RF ablation: MR imaging follow-up.
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Chemoembolization for Hepatocellular Carcinoma: Where Does the Truth Lie?
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Real-time MR Properties of Particulate Embolic Agents Tested in a Dynamic Flow Model
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Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,854
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,759
Progress in applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Thanh, N. T. K., Jones, S. K., & Dobson, J. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224001 · Cited by 1,452
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Metadata
- Authors
- Wilson, M. W., Kerlan, R. K., Fidelman, N. A., Venook, A. P., LaBerge, J. M., Koda, J., & Gordon, R. L.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Radiology
- Published
- 2004-01
- Volume
- 230
- Issue
- 1
- Pages
- 287-293
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2169532237
- Cited by
- 190
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- hepatocellular carcinoma, doxorubicin, hepatic artery, fluoroscopic guidance, tumor targeting, inoperable liver cancer
- MeSH terms
- Adult, Aged, Angiography, Antibiotics, Antineoplastic, Doxorubicin, Drug Carriers, Equipment Design, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Magnetics, Male, Middle Aged
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