Adrenoleukodystrophy: correlating MR imaging with CT.
Abstract
The effect on the brain of the sex-linked recessive form of adrenoleukodystrophy was studied in 40 boys, 4-18 years old. All underwent computed tomography (CT) scanning; six underwent magnetic resonance (MR) imaging. MR showed a high sensitivity in demonstrating white matter disease. Auditory pathway disease was characterized as involvement of the lateral lemniscus and medial geniculate body, and visual pathway disease was characterized by lateral geniculate body, Meyer loop, and optic radiation involvement. Contrast-enhanced CT still proved to have a greater capacity (at this time) to show the active, advancing form of the disease and concomitant calcifications. This large CT series also demonstrated the broad and variable expressions of adrenoleukodystrophy, which allowed the unification of previously described atypical forms of the disease.
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In patients with X-ALD, MRI investigation of the brain can demonstrate characteristic abnormalities.
“If these symptoms are due to X-ALD, MRI investigation of the brain can demonstrate characteristic abnormalities [Kumar et al., 1987].”
From ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: Role in diagnosis and clinical correlations (2001) · cites this paper as Kumar et al., 1987
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Moser, H. W., Mahmood, A., & Raymond, G. V. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0421 · Cited by 663 · see citing works
Aubourg, P., Blanche, S., Jambaqué, I., Rocchiccioli, F., Kalifa, G., Naud-Saudreau, C., Rolland, M.-O., Debré, M., Chaussain, J.-L., Griscelli, C., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006283222607 · Cited by 366 · see citing works
Kemp, S., Pujol, A., Waterham, H. R., van Geel, B. M., Boehm, C. D., Raymond, G. V., Cutting, G. R., Wanders, R. J. A., & Moser, H. W. (2001) · Human Mutation · doi:10.1002/humu.1227 · Cited by 332 · see citing works
Peroxisomal Disorders: Genotype, Phenotype, Major Neuropathologic Lesions, and Pathogenesis
Powers, J. M., & Moser, H. W. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00139.x · Cited by 208 · see citing works
Adrenoleukodystrophy: New Approaches to a Neurodegenerative Disease
Moser, H. W., Raymond, G. V., & Dubey, P. (2005) · JAMA · doi:10.1001/jama.294.24.3131 · Cited by 142 · see citing works
The MR spectrum of peroxisomal disorders
van der Knaap, M. S., & Valk, J. (1991) · Neuroradiology · doi:10.1007/bf00593330 · Cited by 76 · see citing works
- Authors
- Kumar, A. J., Rosenbaum, A. E., Naidu, S., Wener, L., Citrin, C. M., Lindenberg, R., Kim, W. S., Zinreich, S. J., Molliver, M. E., & Mayberg, H. S.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Radiology
- Published
- 1987-11
- Volume
- 165
- Issue
- 2
- Pages
- 497-504
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2025462022
- Cited by
- 120
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 2 · 2012: 2
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- adrenoleukodystrophy, white matter disease, lateral lemniscus, medial geniculate body, lateral geniculate nucleus, optic radiation, cerebral calcification, magnetic resonance imaging, computed tomography, pediatric patients
- MeSH terms
- Adolescent, Adrenoleukodystrophy, Brain, Diffuse Cerebral Sclerosis of Schilder, Child, Child, Preschool, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed
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