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Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media.
Abstract
A large-scale (337,647 cases), nationwide comparative clinical study in Japan on adverse drug reactions (ADRs) to high-osmolar ionic contrast media and low-osmolar nonionic contrast media was performed prospectively. Ionic contrast media were administered in 169,284 cases (50.1%) and nonionic contrast media in 168,363 cases (49.9%). The overall prevalence of ADRs was 12.66% in the ionic contrast media group and 3.13% in the nonionic contrast media group. Severe ADRs occurred in 0.22% of the ionic and 0.04% of the nonionic contrast media examinations. One death occurred in each group, but a causal relationship to the contrast medium could not be established. It is concluded that nonionic contrast media significantly reduce the frequency of severe and potentially life-threatening ADRs to contrast media at all levels of risk and that use of these media represents the most effective means of increasing the safety of contrast media examinations.
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Metadata
- Authors
- Katayama, H., Yamaguchi, K., Kozuka, T., Takashima, T., Seez, P., & Matsuura, K.
- Venue
- Radiology
- Published
- 1990-06
- Volume
- 175
- Issue
- 3
- Pages
- 621-628
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2148815670
- Cited by
- 1,474
- References
- 0
- FWCI
- 91.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. https://app.cochat.ai/papers/10.1148/radiology.175.3.2343107
- The paper
- Katayama, H., Yamaguchi, K., Kozuka, T., Takashima, T., Seez, P., & Matsuura, K. (1990). Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology. https://doi.org/10.1148/radiology.175.3.2343107
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