The DOI matches its Crossref record.
Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.
Abstract
PURPOSE: To determine whether hydrogen-1 magnetic resonance (MR) spectroscopy of the brain allows detection of subclinical hepatic encephalopathy (SCHE). MATERIALS AND METHODS: In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased cerebral glutamine (> 1 SD from normal)--in 20 patients with cirrhosis. RESULTS: Concordance between MR spectroscopic and neuropsychiatric test results was 94% (kappa = 0.84). MR spectroscopy allowed diagnosis of SCHE in nine of nine patients (100%) and of HE in seven of eight (88%). Myo-inositol depletion alone had 80%-85% sensitivity for detection of HE and SCHE. CONCLUSION: H-1 MR spectroscopy allows accurate diagnosis of SCHE, and the results suggest an important role for myo-inositol in psychomotor and visuopractic functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ferenci, P., Lockwood, A., Mullen, K., Tarter, R., Weissenborn, K., & Blei, A. T. (2002) · Hepatology · doi:10.1053/jhep.2002.31250 · Cited by 2,043
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Pathogenetic mechanisms of hepatic encephalopathy
Häussinger, D., & Schliess, F. (2008) · Gut · doi:10.1136/gut.2007.122176 · Cited by 389
MR Imaging Findings in Hepatic Encephalopathy
Rovira, A., Alonso, J., & Córdoba, J. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1139 · Cited by 358
Characteristics of Minimal Hepatic Encephalopathy
Amodio, P., Montagnese, S., Gatta, A., & Morgan, M. Y. (2004) · Metabolic Brain Disease · doi:10.1023/b:mebr.0000043975.01841.de · Cited by 292
Metadata
- Authors
- Ross, B. D., Jacobson, S., Villamil, F., Korula, J., Kreis, R., Ernst, T., Shonk, T., & Moats, R. A.
- Venue
- Radiology
- Published
- 1994-11
- Volume
- 193
- Issue
- 2
- Pages
- 457-463
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2016763168
- Cited by
- 213
- References
- 0
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. https://app.cochat.ai/papers/10.1148/radiology.193.2.7972763
- The paper
- Ross, B. D., Jacobson, S., Villamil, F., Korula, J., Kreis, R., Ernst, T., Shonk, T., & Moats, R. A. (1994). Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology. https://doi.org/10.1148/radiology.193.2.7972763
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
