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Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions.
Abstract
PURPOSE: To assess the safety and diagnostic efficacy of intravenous ferumoxides, a superparamagnetic iron oxide, for depiction of focal hepatic lesions on magnetic resonance (MR) images. MATERIALS AND METHODS: This open-label study included 208 patients with known or suspected focal hepatic lesions. MR images were obtained before and 45 minutes to 4 hours after intravenous infusion of ferumoxides (10 mumol/kg). The effect of ferumoxides on signal intensity of the liver was assessed with quantitative analysis. Safety was evaluated with patient monitoring and laboratory measurements. RESULTS: Mean lesion-to-liver contrast-to-noise ratio on T2-weighted images was 9.1 on unenhanced images and 12.7 on enhanced images. Signal intensity of normal liver on enhanced images decreased to 37% of that on unenhanced images. In blinded image evaluations, additional lesions were identified on 27% of enhanced images. No serious adverse events occurred. CONCLUSION: Ferumoxides is a safe and efficacious contrast agent for the detection of focal liver lesions on T2-weighted images.
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Citations
Cited by
Wang, Y.-X. J., Hussain, S. M., & Krestin, G. P. (2001) · European Radiology · doi:10.1007/s003300100908 · Cited by 1,381
Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.192 · Cited by 500
Huppertz, A., Balzer, T., Blakeborough, A., Breuer, J., Giovagnoni, A., Heinz-Peer, G., Laniado, M., Manfredi, R. M., Mathieu, D. G., Mueller, D., et al. (2004) · Radiology · doi:10.1148/radiol.2301020269 · Cited by 396
Bonnemain, B. (1998) · Journal of Drug Targeting · doi:10.3109/10611869808997890 · Cited by 371
Engineered nanoparticles for biomolecular imaging
Mahmoudi, M., Serpooshan, V., & Laurent, S. (2011) · Nanoscale · doi:10.1039/c1nr10326a · Cited by 262
Metadata
- Authors
- Ros, P. R., Freeny, P. C., Harms, S. E., Seltzer, S. E., Davis, P. L., Chan, T. W., Stillman, A. E., Muroff, L. R., Runge, V. M., & Nissenbaum, M. A.
- Venue
- Radiology
- Published
- 1995-08
- Volume
- 196
- Issue
- 2
- Pages
- 481-488
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2051421116
- Cited by
- 278
- References
- 0
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. https://app.cochat.ai/papers/10.1148/radiology.196.2.7617864
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- Ros, P. R., Freeny, P. C., Harms, S. E., Seltzer, S. E., Davis, P. L., Chan, T. W., Stillman, A. E., Muroff, L. R., Runge, V. M., & Nissenbaum, M. A. (1995). Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. Radiology. https://doi.org/10.1148/radiology.196.2.7617864
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