The DOI matches its Crossref record.
Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose.
Abstract
PURPOSE: To quantify the activity of joint inflammation with magnetic resonance (MR) imaging and positron emission tomography (PET). MATERIALS AND METHODS: Gadolinium-enhanced MR imaging and 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) PET of the wrist were performed prospectively in 12 patients receiving antiinflammatory therapy. Patients were studied three times: off medications for 2 weeks, after 2 weeks of treatment with prednisone or nonsteroid antiinflammatory drugs, and after 12 weeks of treatment with methotrexate. Volume of enhancing pannus (VEP) was determined from fat-suppressed MR images (12 patients). FDG uptake was calculated from PET images (11 patients). RESULTS: VEP and FDG uptake were closely correlated (r > .86, P < .0001), as were changes in VEP and standardized uptake volume (r > .91, P < .0002). VEP and FDG uptake were strongly associated with clinical findings in wrists (P < .002) but not with treatment outcomes (P > .05). CONCLUSION: Contrast material-enhanced MR imaging and PET allow quantification of volumetric and metabolic changes in joint inflammation and comparison of efficacies of antiinflammatory drugs.
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Cited by
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Peterfy, C. G., Guermazi, A., Zaim, S., Tirman, P. F. J., Miaux, Y., White, D., Kothari, M., Lu, Y., Fye, K., Zhao, S., et al. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2003.11.003 · Cited by 1,540
Moog, F., Bangerter, M., Kotzerke, J., Guhlmann, A., Frickhofen, N., & Reske, S. N. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.603 · Cited by 277
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Metadata
- Authors
- Palmer, W. E., Rosenthal, D. I., Schoenberg, O. I., Fischman, A. J., Simon, L. S., Rubin, R. H., & Polisson, R. P.
- Venue
- Radiology
- Published
- 1995-09
- Volume
- 196
- Issue
- 3
- Pages
- 647-655
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2087419867
- Cited by
- 224
- References
- 0
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. https://app.cochat.ai/papers/10.1148/radiology.196.3.7644624
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- Palmer, W. E., Rosenthal, D. I., Schoenberg, O. I., Fischman, A. J., Simon, L. S., Rubin, R. H., & Polisson, R. P. (1995). Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology. https://doi.org/10.1148/radiology.196.3.7644624
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