The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration
Abstract
This study was designed to identify the molecular mechanisms of phosphatidylinositol 3-kinase (PI3K)-induced actin filament remodeling and cell migration. Expression of active forms of PI3K, v-P3k or Myr-P3k, was sufficient to induce actin filament remodeling to lead to an increase in cell migration, as well as the activation of Akt in chicken embryo fibroblast (CEF) cells. Either the inhibition of PI3K activity using a PI3K-specific inhibitor, LY-294002, or the disruption of Akt activity restored the integrity of actin filaments in CEF cells and inhibited PI3K-induced cell migration. We also found that expression of an activated form of Akt (Myr-Akt) was sufficient to remodel actin filaments to lead to an increase in cell migration, which was unable to be inhibited by the presence of LY-294002. Furthermore, we found that p70S6K1 kinase was a downstream molecule that can mediate the effects of both PI3K and Akt on actin filaments and cell migration. Overexpression of an active form of p70S6K1 was sufficient to induce actin filament remodeling and cell migration in CEF cells, which requires Rac activity. These results demonstrate that activation of PI3K activity alone is sufficient to remodel actin filaments to increase cell migration through the activation of Akt and p70S6K1 in CEF cells.
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Cites
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Cited by
Metal-induced oxidative stress and signal transduction
Leonard, S. S., Harris, G. K., & Shi, X. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.010 · Cited by 663
Self-citationOncogenic Ras in tumour progression and metastasis
Giehl, K. (2005) · Biological Chemistry · doi:10.1515/bc.2005.025 · Cited by 287
PKB/Akt-Dependent Regulation of Cell Motility
Xue, G., & Hemmings, B. A. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs648 · Cited by 265
Metadata
- Authors
- Qian, Y., Corum, L., Meng, Q., Blenis, J., Zheng, J. Z., Shi, X., Flynn, D. C., & Jiang, B.-H.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2004-01
- Volume
- 286
- Issue
- 1
- Pages
- C153-C163
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2145822440
- Cited by
- 192
- References
- 1
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Qian, Y., Corum, L., Meng, Q., Blenis, J., Zheng, J. Z., Shi, X., Flynn, D. C., & Jiang, B.-H. (2004). PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00142.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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