The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis
Abstract
An attempt is made to elucidate the cellular mechanisms which may account for the well-documented correlation between sodium metabolism and peripheral vascular resistance. As a starting point, the evidence that the Na electrochemical gradient across the vascular smooth muscle cell plasma membrane (sarcolemma) plays an important role in cell calcium regulation is reviewed. Because there is significant resting tension (“tone”) in most resistance vessels, the ionized Ca2+ level ([Ca2+]1) in the smooth muscle fibers in these vessels must be maintained above the contraction threshold. Consequently, the Ca transport system in the sarcolemma, presumably an Na-Ca exchange mechanism, must be set so as to hold [Ca2+]1 at this suprathreshold level. Any change in the Na gradient will then be reflected as a change in [Ca2+]1 and, therefore, in steady vessel wall tension and peripheral resistance. The correlation between Na metabolism and hypertension could then be accounted for if a circulating agent, perhaps the “natriuretic hormone,” affects the Na gradient (across the sarcolemma) and, therefore, [Ca2+]1 and tension.
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Citations
Cites
The dependence of calcium efflux from cardiac muscle on temperature and external ion composition
Reuter, H., & Seitz, N. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008467 · Cited by 1,023
The influence of calcium on sodium efflux in squid axons
Baker, P. F., Blaustein, M. P., Hodgkin, A. L., & Steinhardt, R. A. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008702 · Cited by 962
Self-citationCirculation: Overall Regulation
Guyton, A. C., Coleman, T. G., & Granger, H. J. (1972) · Annual Review of Physiology · doi:10.1146/annurev.ph.34.030172.000305 · Cited by 870
THE SARCOPLASMIC RETICULUM AND TRANSVERSE TUBULES OF THE FROG'S SARTORIUS
Peachey, L. D. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.25.3.209 · Cited by 683
The interrelationship between sodium and calcium fluxes across cell membranes
Blaustein, M. P. (2005) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0034293 · Cited by 598
Self-citationSARCOPLASMIC RETICULUM AND EXCITATION-CONTRACTION COUPLING IN MAMMALIAN SMOOTH MUSCLES
Devine, C. E., Somlyo, A. V., & Somlyo, A. P. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.52.3.690 · Cited by 522
Relaxing factor and the relaxation of muscle
Hasselbach, W. (1964) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(64)80006-7 · Cited by 472
The role of humoral agents in volume expanded hypertension
Haddy, F. J., & Overbeck, H. W. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90284-8 · Cited by 401
Rüegg, J. C. (1971) · Physiological Reviews · doi:10.1152/physrev.1971.51.1.201 · Cited by 338
Mason, D. T., Braunwald, E., Karsh, R. B., & Bullock, F. A. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104939 · Cited by 322
Cited by
Mechanisms of sodium pump regulation
Therien, A. G., & Blostein, R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c541 · Cited by 765
Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle
Droogmans, G., & Casteels, R. (1984) · Developments in Cardiovascular Medicine · doi:10.1007/978-1-4757-1171-4_35 · Cited by 431
de Wardener, H. E., & MacGregor, G. A. (1980) · Kidney International · doi:10.1038/ki.1980.104 · Cited by 375
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension
Blaustein, M. P., Leenen, F. H. H., Chen, L., Golovina, V. A., Hamlyn, J. M., Pallone, T. L., Van Huysse, J. W., Zhang, J., & Wier, W. G. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00899.2011 · Cited by 285
Self-citationCalcium metabolism and parathyroid function in primary aldosteronism
Resnick, L. M., & Laragh, J. H. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90328-6 · Cited by 111
Metadata
- Authors
- Blaustein, M. P.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1977-05-01
- Volume
- 232
- Issue
- 5
- Pages
- C165-C173
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2121020585
- Cited by
- 1,310
- References
- 17
- FWCI
- 19.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blaustein, M. P. (1977). Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1977.232.5.c165
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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