The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
AMP deamination and IMP reamination in working skeletal muscle
Abstract
The extent of purine nucleotide cycle (PNC) turnover [i.e., the cyclic deamination of adenosine 5'-monophosphate (AMP) and reamination of inosine 5'-monophosphate (IMP)] was estimated in fast-twitch muscle of pentobarbital sodium anesthetized rats during in situ stimulation, by the accumulation of excess IMP after blocking IMP reamination with the adenylosuccinate synthetase inhibitor, hadacidin. Sodium hadacidin (100 mg/kg, iv) did not alter IMP production and was effective in blocking IMP reamination by 80%. Hadacidin had no effect on IMP levels in muscle at rest or during mild stimulation (1 Hz for 30 min). During 30 min of more intense stimulation (5 Hz), hadacidin treatment resulted in a threefold increase in IMP in the fast-twitch white gastrocnemius section, but had no effect in the fast-twitch red section. The IMP in the fast-twitch white section did not accumulate over the 30-min period, but was produced initially (within 5 min) and kept for being reaminated by hadacidin. Thus, the IMP formation and IMP reamination evident in the saline-injected animals did not occur concurrently. This suggests that the IMP reamination arm of the PNC is not an important pathway in "working" muscle.
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“The exercise dependent increase in skeletal muscle AMP [10] is thought to not only allosterically activate glycolysis [11] but also activate the evolutionary conserved fuel gauge protein AMP-activated protein kinase (AMPK) [12].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [10]
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HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS
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Ammonia production in muscle and other tissues: the purine nucleotide cycle.
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Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise
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Self-citationOxygen uptake of rats at different work intensities
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Effect of exercise on AMP deaminase and adenylosuccinase in rat skeletal muscle
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Self-citationOGAWA, H., Shiraki, H., Matsuda, Y., Kakiuchi, K., & Nakagawa, H. (1977) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131550 · Cited by 33
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Effects of alanosine and hadacidin on enzymes using aspartic acid as a metabolite
Laue, M. C., Yip, B. P., & Rudolph, F. B. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90098-3 · Cited by 9
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Chemical energetics of slow- and fast-twitch muscles of the mouse.
Crow, M. T., & Kushmerick, M. J. (1982) · The Journal of General Physiology · doi:10.1085/jgp.79.1.147 · Cited by 543
Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism
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The use and abuse of fish otoliths in studies of feeding habits of marine piscivores
Jobling, M., & Breiby, A. (1986) · Sarsia · doi:10.1080/00364827.1986.10419696 · Cited by 346
Caffeine, performance, and metabolism during repeated Wingate exercise tests
Greer, F. A., McLean, C., & Graham, T. E. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1502 · Cited by 243
New strategies in sport nutrition to increase exercise performance
Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221
Metadata
- Authors
- Meyer, R. A., & Terjung, R. L.
- Affiliations
- SUNY Upstate Medical University (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1980-07-01
- Volume
- 239
- Issue
- 1
- Pages
- C32-C38
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W119330955
- Cited by
- 143
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- purine nucleotide cycle, AMP deamination, adenylosuccinate synthetase, hadacidin, skeletal muscle, fast-twitch muscle, inosine 5'-monophosphate, muscle stimulation, gastrocnemius, red and white muscle fibers
- MeSH terms
- Adenosine Diphosphate, Adenosine Monophosphate, Adenosine Triphosphate, Ammonia, Animals, Physical Exertion, Formaldehyde, Glycine, Inosine Monophosphate, Inosine Nucleotides, Lactates, Male, Muscle Contraction, Muscles, Phosphocreatine, Rats
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