Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death

Gbadegesin, Muyiwa; Vicini, Stefano; Hewett, Sandra J.; Wink, David A.; Espey, Michael; Pluta, Ryszard M.; Colton, Carol A.

doi:10.1152/ajpcell.1999.277.4.c673

Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death

Nitric oxide (NO) released from a new chemical class of donors enhances N-methyl-d-aspartate (NMDA) channel activity. Using whole cell and single-channel patch-clamp techniques, we have shown that ( Z)-1-[ N-(3-ammoniopropyl)- N-( n-propyl)amino]-NO (PAPA-NO) and diethylamine NO, commonly termed …