The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Heterogeneity of pig intestinal d-glucose transport systems
Abstract
Heterogeneity of intestinald-glucose transport is demonstrated using pig jejunal brush-border membrane vesicles in the presence of 100/0 (out/in) mM gradients each of NaCl, NaSCN, and KSCN. Two d-glucose transport systems are kinetically distinguished: high-affinity, low-capacity system 1, which is equivalent to the symporter SGLT1; and low-affinity, high-capacity system 2, which is not a member of the SGLT family but is a d-glucose and d-mannose transporter exhibiting no preference for Na+over K+. A nonsaturabled-glucose uptake component has also been detected; uptake of this component takes place at rates 10 times the rate of components characterizing the classical diffusion marker l-glucose. It is also shown that, in this kinetic work, 1) use of d-glucose-contaminatedd-sorbitol as an osmotic replacement cannot cause the spurious appearance of nonexistent transport systems and 2) a large range (≥50 mM) of substrate concentrations is required to correctly fit substrate saturation curves to distinguish between low-affinity transport systems and physical diffusion.
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“Defects in skeletal muscle oxidative capacity and fat metabolism are highly correlated with insulin sensitivity (IS) (1,5,12) and are believed to contribute to the pathogenesis of insulin resistance (13,14).”
From Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor (2005) · cites this paper as [5]
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Cites
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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670
Metabolites as regulators of insulin sensitivity and metabolism
Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 698
Heilbronn, L. K., Smith, S. R., & Ravussin, É. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802853 · Cited by 416
Collins, A. R., Meehan, W. P., Kintscher, U., Jackson, S. M., Wakino, S., Noh, G. J., Palinski, W., Hsueh, W. A., & Law, R. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.365 · Cited by 389
Metadata
- Authors
- Halaihel, N., Gerbaud, D., Vasseur, M., & Alvarado, F.
- Affiliations
- Inserm (FR)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1999-12-01
- Volume
- 277
- Issue
- 6
- Pages
- C1130-C1141
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2613483351
- Cited by
- 199
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 10
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- intestinal glucose transport, SGLT1, brush border membrane vesicles, substrate saturation kinetics, sorbitol
- MeSH terms
- Animals, Biological Transport, Diffusion, Coloring Agents, Glucose, Intestinal Absorption, Intestinal Mucosa, Intracellular Membranes, Kinetics, Mannose, Membrane Glycoproteins, Monosaccharide Transport Proteins, Osmosis, Sodium Chloride, Sorbitol, Swine, Thiocyanates, Sodium-Glucose Transporter 1
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