CoChat
Sign Up
Cited by 313Bariatric Surgery and OutcomesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

Jørgensen, N. B., Jacobsen, S. H., Dirksen, C., Bojsen-Møller, K. N., Naver, L., Hvolris, L., Clausen, T. R., Wulff, B. S., Worm, D., Lindqvist Hansen, D., Madsbad, S., Holst, J. J.·2012·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00073.2012
Open this paper in CoChat — free account

Abstract

Our aim was to study the potential mechanisms responsible for the improvement in glucose control in Type 2 diabetes (T2D) within days after Roux-en-Y gastric bypass (RYGB). Thirteen obese subjects with T2D and twelve matched subjects with normal glucose tolerance (NGT) were examined during a liquid meal before (Pre), 1 wk, 3 mo, and 1 yr after RYGB. Glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), glucose-dependent-insulinotropic polypeptide (GIP), and glucagon concentrations were measured. Insulin resistance (HOMA-IR), β-cell glucose sensitivity (β-GS), and disposition index (D(β-GS): β-GS × 1/HOMA-IR) were calculated. Within the first week after RYGB, fasting glucose [T2D Pre: 8.8 ± 2.3, 1 wk: 7.0 ± 1.2 (P < 0.001)], and insulin concentrations decreased significantly in both groups. At 129 min, glucose concentrations decreased in T2D [Pre: 11.4 ± 3, 1 wk: 8.2 ± 2 (P = 0.003)] but not in NGT. HOMA-IR decreased by 50% in both groups. β-GS increased in T2D [Pre: 1.03 ± 0.49, 1 wk: 1.70 ± 1.2, (P = 0.012)] but did not change in NGT. The increase in DI(β-GS) was 3-fold in T2D and 1.5-fold in NGT. After RYGB, glucagon secretion was increased in response to the meal. GIP secretion was unchanged, while GLP-1 secretion increased more than 10-fold in both groups. The changes induced by RYGB were sustained or further enhanced 3 mo and 1 yr after surgery. Improvement in glycemic control in T2D after RYGB occurs within days after surgery and is associated with increased insulin sensitivity and improved β-cell function, the latter of which may be explained by dramatic increases in GLP-1 secretion.

Overview

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00073.2012

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 49 references

Research works printed but not linked: 2

  1. Shah P, 2000, J Clin Endocrinol Metab, 85, 4053
  2. Wing RR, 2010, Arch Intern Med, 170, 1566

Cited by

Sorted by citations

Items 201–300 of 312

Related

See all

Metadata

Authors
Jørgensen, N. B., Jacobsen, S. H., Dirksen, C., Bojsen-Møller, K. N., Naver, L., Hvolris, L., Clausen, T. R., Wulff, B. S., Worm, D., Lindqvist Hansen, D., Madsbad, S., & Holst, J. J.
Affiliations
  • University of Copenhagen (DK)
  • Hvidovre Hospital (DK)
  • Novo Nordisk (Denmark) (DK)
  • Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark;
Corresponding author
Jørgensen, N. B.
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2012-07-01
Volume
303
Issue
1
Pages
E122-E131
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00073.2012
OpenAlex
W2129549955
Cited by
313
References
49
Citations by year
2026: 6 · 2025: 14 · 2024: 11 · 2023: 15 · 2022: 20 · 2021: 27 · 2020: 17 · 2019: 36 · 2018: 22 · 2017: 30 · 2016: 28 · 2015: 32 · 2014: 16 · 2013: 34 · 2012: 4
FWCI
28.01
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
Roux-en-Y gastric bypass, type 2 diabetes, glucose metabolism, insulin resistance, beta-cell function, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, glucagon, C-peptide, insulin secretion, bariatric surgery, obesity, glycemic control, insulin sensitivity
MeSH terms
Adult, C-Peptide, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glucagon, Glucose, Humans, Hyperglycemia, Insulin Resistance, Male, Middle Aged, Obesity, Obesity, Morbid, Time Factors, Gastric Bypass, Body Mass Index, Postprandial Period, Insulin-Secreting Cells, Glucagon-Like Peptide 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review