The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
Abstract
Some, but not all, fats are obesogenic. The aim of the present studies was to investigate the effects of changing type and amount of dietary fats on energy balance, fat deposition, leptin, and leptin-related neural peptides: leptin receptor, neuropeptide Y (NPY), agouti-related peptide (AgRP), and proopiomelanocortin (POMC), in C57Bl/6J mice. One week of feeding with a highly saturated fat diet resulted in ∼50 and 20% reduction in hypothalamic arcuate NPY and AgRP mRNA levels, respectively, compared with a low-fat or an n-3 or n-6 polyunsaturated high-fat (PUFA) diet without change in energy intake, fat mass, plasma leptin levels, and leptin receptor or POMC mRNA. Similar neuropeptide results were seen at 7 wk, but by then epididymal fat mass and plasma leptin levels were significantly elevated in the saturated fat group compared with low-fat controls. In contrast, fat and leptin levels were reduced in the n-3 PUFA group compared with all other groups. At 7 wk, changing the saturated fat group to n-3 PUFA for 4 wk completely reversed the hyperleptinemia and increased adiposity and neuropeptide changes induced by saturated fat. Changing to a low-fat diet was much less effective. In summary, a highly saturated fat diet induces obesity without hyperphagia. A regulatory reduction in NPY and AgRP mRNA levels is unable to effectively counteract this obesogenic drive. Equally high fat diets emphasizing PUFAs may even protect against obesity.
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“In the diet-induced obese mouse, when hypothalamic NPY mRNA expression was reduced, AgRP and POMC mRNA were also downregulated (Lin et al., 2000; Wang et al., 2002).”
From Cigarette Smoking and Brain Regulation of Energy Homeostasis (2012) · cites this paper as Wang et al., 2002
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Cites
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Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
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“Conversely, overexpression of Arc NPY mRNA has been reported in mice that lack leptin (ob/ob) and in leptin receptor-deficient db/db mice (14, 18).”
Background
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Cited by
Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons
Enriori, P. J., Evans, A. E., Sinnayah, P., Jobst, E. E., Tonelli-Lemos, L., Billes, S. K., Glavas, M. M., Grayson, B. E., Perello, M., Nillni, E. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.004 · Cited by 552
Energy balance and body composition in sports and exercise
Loucks, A. B. (2004) · Journal of Sports Sciences · doi:10.1080/0264041031000140518 · Cited by 344
Long-term metabolic risk among children born premature or small for gestational age.
Mericq, V., Martinez-Aguayo, A., Uauy, R., Iñiguez, G., Van der Steen, M., & Hokken-Koelega, A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.127 · Cited by 257
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Wang, H., Astarita, G., Taussig, M. D., Bharadwaj, K. G., DiPatrizio, N. V., Nave, K.-A., Piomelli, D., Goldberg, I. J., & Eckel, R. H. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.006 · Cited by 139
Self-citation
Metadata
- Authors
- Wang, H., Storlien, L. H., & Huang, X.-F.
- Affiliations
- Metabolic Research Center, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-06-01
- Volume
- 282
- Issue
- 6
- Pages
- E1352-E1359
- ISSN
- 0193-1849
- 1522-1555
- Cited by
- 201
- References
- 3
- Language
- en
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