Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women
Abstract
We examined expression and activity of steroid aldoketoreductase (AKR) 1C enzymes in adipose tissue in women. AKR1C1 (20alpha-hydroxysteroid dehydrogenase; 20alpha-HSD), AKR1C2 (3alpha-HSD-3), and AKR1C3 (17beta-HSD-5) are involved mainly in conversion of progesterone to 20alpha-hydroxyprogesterone and inactivation of dihydrotestosterone to 5alpha-androstane-3alpha,17beta-diol. Abdominal subcutaneous and omental adipose tissue biopsies were obtained during abdominal hysterectomies in seven women with low visceral adipose tissue (VAT) area and seven age- and total body fat mass-matched women with visceral obesity. Women with elevated VAT areas were characterized by significantly higher omental adipose tissue 20alpha-HSD and 3alpha-HSD-3 mRNA abundance compared with women with low VAT accumulations (1.4- and 1.6-fold differences, respectively; P < 0.05). Omental and subcutaneous adipose tissue 3alpha-HSD activities were significantly higher in women with high vs. low VAT areas (P < 0.05 for both comparisons). Total and visceral adiposities were positively associated with omental 20alpha-HSD mRNA level (r = 0.75, P < 0.003 for fat mass; r = 0.57, P < 0.04 for VAT area) and omental 3alpha-HSD-3 mRNA level (r = 0.68, P < 0.01 for fat mass; r = 0.74, P < 0.003 for VAT area). Enzyme activities in both depots were also positively correlated with adiposity measures. Omental adipose tissue enzyme expression and activity were positively associated with omental adipocyte size and LPL activity. In conclusion, mRNA abundance and activity of AKR1C enzymes in abdominal adipose tissue compartments are positive correlates of adiposity in women. Increased progesterone and/or dihydrotestosterone reduction in abdominal adipose tissue may impact locally on fat cell metabolism.
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The expression and activity of AKR1C1, AKR1C2 and AKR1C3 correlates with obesity in women and men.
“and their expression and activity correlates with obesity in women and men (Blouin et al., 2005, Blouin et al., 2006).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Blouin et al., 2005
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References 38 · Cited by 67
- Authors
- Blouin, K., Blanchette, S., Richard, C., Dupont, P., Luu-The, V., & Tchernof, A.
- Affiliations
- Université Laval (CA)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 288
- Issue
- 2
- Pages
- E398-E404
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2154734204
- Cited by
- 67
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 3
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Corpus Université Laval (Université Laval) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- AKR1C1, AKR1C2, AKR1C3, 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, omental adipose tissue, visceral fat, subcutaneous adipose tissue, women, progesterone metabolism, adipocyte size, lipoprotein lipase activity, enzyme expression
- MeSH terms
- Aldo-Keto Reductases, Aldo-Keto Reductase Family 1 Member C3, Adipose Tissue, Alcohol Oxidoreductases, Aldehyde Reductase, Body Composition, Enzyme Activation, Female, Humans, Hydroxyprostaglandin Dehydrogenases, Hydroxysteroid Dehydrogenases, Middle Aged, Obesity, Omentum, Statistics as Topic, Steroids, Tissue Distribution, 20-Hydroxysteroid Dehydrogenases, 3-Hydroxysteroid Dehydrogenases, Biomarkers, Gene Expression Regulation, Enzymologic, 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
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