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Cited by 7Metabolism, Diabetes, and CancerPancreatic function and diabetesGlycogen Storage Diseases and Myoclonus

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

Open access
Coate, Katie C., Ramnanan, Christopher J., Smith, Marta, Winnick, Jason J., Kraft, Guillaume, Irimia-Dominguez, Jose, Farmer, Ben, Donahue, E. Patrick, Roach, Peter J., Cherrington, Alan D., Edgerton, Dale S.·2024·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00316.2023PMC PMC11193521

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Abstract

Glucagon rapidly stimulates hepatic glucose production, but these effects are transient. This study links the molecular and metabolic flux changes that occur in the liver over time in response to a rise in glucagon, demonstrating the strength of the dog as a translational model to couple findings in small animals and humans. In addition, this study clarifies why the rapid effects of glucagon on liver glycogen metabolism are not sustained.

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Integrity signals

Registry

Crossref · 10.1152/ajpendo.00316.2023

Cites

11 of 11 references verified0 citation errors · 0 not checkable

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  • Coate and Ramnanan investigated the molecular and metabolic flux changes occurring in the liver in response to a rise in glucagon, clarifying why the glucagon effect is not sustained.

    “More recently, Coate and Ramnanan investigated the molecular and metabolic flux changes occurring in the liver in response to a rise in glucagon, clarifying why the glucagon effect is not sustained [21].”

    From Modeling the effect of glucagon on endogenous glucose production in healthy individuals under meal-like conditions (2025) · cites this paper as [21]

Citations

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Research works printed but not linked: 69

  1. 10.1172/JCI108641 · DOI
  2. 10.1152/ajpendo.1989.257.1.E108 · DOI · Paper page
  3. 10.5152/UCD.2014.265 · DOI
  4. 10.1152/ajpendo.1989.256.5.E651 · DOI
  5. 10.2337/diab.28.6.533 · DOI
  6. 10.1016/s0140-6736(75)92375-2 · DOI · Paper page
  7. 10.1152/ajpendo.90887.2008 · DOI
  8. 10.1016/j.amjmed.2009.12.008 · DOI
  9. 10.2337/db09-1625 · DOI
  10. 10.1172/JCI45472 · DOI
  11. 10.1016/0014-5793(79)80515-3 · DOI
  12. 10.1042/BJ20111416 · DOI
  13. 10.1016/S0021-9258(19)75689-0 · DOI
  14. 10.1016/0003-2697(68)90127-9 · DOI
  15. 10.1210/jendso/bvab088 · DOI
  16. 10.1111/j.2517-6161.1995.tb02031.x · DOI · Paper page
  17. 10.1016/j.cels.2015.12.004 · DOI · Paper page
  18. 10.2337/diabetes.50.8.1872 · DOI
  19. 10.2337/diabetes.53.1.32 · DOI
  20. 10.2337/diabetes.51.6.1663 · DOI
  21. 10.1016/s0169-2607(02)00097-4 · DOI
  22. 10.1146/annurev.nu.16.070196.001143 · DOI · Paper page
  23. 10.1016/j.molmet.2023.101703 · DOI
  24. 10.7554/eLife.69521 · DOI
  25. 10.1101/cshperspect.a014225 · DOI
  26. 10.1093/lifemeta/load021 · DOI
  27. 10.2337/diab.31.10.917 · DOI
  28. 10.2337/diabetes.30.3.180 · DOI
  29. 10.1016/s0026-0495(96)90223-1 · DOI
  30. 10.1042/BJ20080595 · DOI
  31. 10.1146/annurev-nutr-071715-051145 · DOI
  32. 10.1074/jbc.275.14.10597 · DOI
  33. 10.1096/fasebj.8.6.8168691 · DOI
  34. 10.2337/diabetes.52.6.1333 · DOI
  35. 10.1042/BJ20031191 · DOI
  36. 10.1042/bj3360019 · DOI
  37. 10.1002/dmr.5610030107 · DOI
  38. 10.1096/fasebj.11.7.9212078 · DOI
  39. 10.2337/db13-0880 · DOI
  40. 10.1146/annurev.bi.57.070188.003543 · DOI
  41. 10.1038/nm.3202 · DOI
  42. 10.1016/s0026-0495(76)80140-0 · DOI
  43. 10.1172/JCI107537 · DOI
  44. 10.14814/phy2.15263 · DOI
  45. 10.1016/j.cmet.2012.03.002 · DOI
  46. 10.1016/j.molmet.2013.11.007 · DOI
  47. 10.1038/nm.3115 · DOI
  48. 10.1152/ajpendo.00304.2022 · DOI
  49. 10.1042/0264-6021:3620513 · DOI
  50. 10.1111/j.1432-1033.1983.tb07784.x · DOI
  51. 10.1016/0026-0495(72)90028-5 · DOI
  52. 10.1210/jc.86.5.2085 · DOI
  53. 10.1210/jcem-72-2-308 · DOI
  54. 10.1007/s00125-012-2464-x · DOI
  55. 10.1172/jci38650 · DOI
  56. 10.1016/j.mce.2012.06.018 · DOI
  57. 10.1172/JCI40919 · DOI
  58. 10.1111/j.1463-1326.2011.01454.x · DOI · Paper page
  59. 10.1016/S0021-9258(20)82102-4 · DOI
  60. 10.1152/ajpendo.1982.242.2.E73 · DOI
  61. 10.1152/ajpendo.00466.2019 · DOI
  62. 10.2337/dbi22-0002 · DOI
  63. 10.1016/j.cmet.2017.05.011 · DOI
  64. 10.1016/j.isci.2022.105296 · DOI
  65. 10.1016/j.celrep.2015.06.034 · DOI
  66. Haynes RC, 1974, Mol Pharmacol, 10, 381
  67. 10.1016/0003-9861(75)90422-1 · DOI
  68. 10.2337/db17-1502 · DOI · Paper page
  69. 10.2337/db20-7-LB · DOI

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Metadata

Authors
Coate, K. C., Ramnanan, C. J., Smith, M., Winnick, J. J., Kraft, G., Irimia-Dominguez, J., Farmer, B., Donahue, E. P., Roach, P. J., Cherrington, A. D., & Edgerton, D. S.
Affiliations
  • Vanderbilt University Medical Center (US)
  • University of Ottawa (CA)
  • Vanderbilt University (US)
  • University of Cincinnati (US)
  • Department of Molecular and Cellular Endocrinology, Beckman Research Institute, Duarte, California, United States
  • Indiana University School of Medicine (US)
Corresponding author
Edgerton, Dale S.
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2024-04-01
Volume
326
Issue
4
Pages
E428-E442
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00316.2023
PMC
PMC11193521
OpenAlex
W4391616236
Cited by
7
References
11
Citations by year
2026: 2 · 2025: 3 · 2024: 2
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK18243, SP-60-AM20593, DK20593)
  • American Diabetes Association (Mentor-based Fellowship)
  • Vanderbilt Jacquelyn A. Turner and Dr. Dorothy J. Turner Chair in Diabetes Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Glycogen Storage Diseases and Myoclonus
Keywords
glucagon signaling, hepatic glucose production, metabolic flux, liver glycogen metabolism, gene expression profiles, canine model, translational model, hepatic glucose metabolism

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