Prenatal exposure to diesel exhaust PM2.5 causes offspring β cell dysfunction in adulthood
Open accessAbstract
Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure to ambient fine particulate matter (PM 2.5) is associated with various fetal abnormalities, suggesting that it may program offspring’s susceptibility to diabetes. In the present study, we therefore examined whether maternal exposure to diesel exhaust PM 2.5 (DEP), one of the major sources of ambient PM 2.5 in urban areas, programs adult offspring’s glucose metabolism. Female C57Bl/6J mice were intratracheally instilled with DEP or vehicle throughout a 7-wk preconceptional period, gestation, and lactation, and the glucose homeostasis of their adult male offspring was assessed. Intraperitoneal glucose tolerance test (IPGTT) revealed that the maternal exposure to DEP significantly impaired adult male offspring’s glucose tolerance. Unexpectedly, it did not influence their insulin sensitivity, whereas it significantly decreased their glucose-induced insulin secretion (GIIS). This deficit in insulin secretion was corroborated by their significant decrease in arginine-induced insulin secretion. Histological analysis demonstrated that the deficit in insulin secretion was accompanied by the decrease in pancreatic islet and β cell sizes. To differentiate the effects of maternal exposure to DEP before birth and during lactation, some offspring were cross-fostered once born. We did not observe any significant effect of cross-fostering on the glucose homeostasis of adult male offspring and the function and morphology of their β cells. Prenatal exposure to DEP programs the morphology and function of β cells and thus homeostatic regulation of glucose metabolism in adult male offspring.
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Prenatal exposure to diesel exhaust PM2.5 in C57Bl/6 mice altered the morphology and function of male offspring pancreatic β cells, correlating with decreased pancreatic islet cell and β cell sizes.
“Chen et al. [86] demonstrated prenatal exposure to DE PM2.5 in C57Bl/6 mice altered the morphology and function of male offspring pancreatic β cells, which are responsible for producing insulin, thus altering glucose metabolism. This deficiency correlated with decreased pancreatic islet cell and β cell sizes.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [86]
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Cited by
Sorted by citations
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
- Authors
- Chen, M., Liang, S., Qin, X., Zhang, L., Qiu, L., Chen, S., Hu, Z., Xu, Y., Wang, W., Zhang, Y., Cao, Q., & Ying, Z.
- Affiliations
- University of Maryland, Baltimore (US)
- Fudan University (CN)
- Corresponding author
- Ying, Zhekang
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2018-07-01
- Volume
- 315
- Issue
- 1
- Pages
- E72-E80
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC6087722
- OpenAlex
- W2775860725
- Cited by
- 37
- References
- 2
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) (R01ES024516)
- National Natural Science Foundation of China (NSFC) (81500216, 81770805)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- diesel exhaust, PM2.5, prenatal exposure, beta-cell dysfunction, glucose tolerance, insulin secretion, glucose-stimulated insulin secretion, pancreatic islets, developmental programming, diabetes susceptibility, cross-fostering, glucose homeostasis, insulin sensitivity
- MeSH terms
- Insulin Secretion, Air Pollutants, Animals, Vehicle Emissions, Female, Glucose, Glucose Tolerance Test, Insulin Resistance, Male, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Exposure, Cell Size, Insulin-Secreting Cells, Mice, Particulate Matter
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