CoChat
Sign Up
Cited by 328Adipose Tissue and MetabolismMetabolism, Diabetes, and CancerCardiovascular and exercise physiology

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Open access
Bruce, Clinton R., Thrush, A. Brianne, Mertz, Valerie A., Bezaire, Veronic, Chabowski, Adrian, Heigenhauser, George J. F., Dyck, David J.·2006·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00587.2005
Open this paper in CoChat — free account

Abstract

Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by reduced rates of FA oxidation and accumulation of lipids. It has been suggested that interventions that increase FA oxidation may enhance insulin action by reducing these lipid pools. Here, we examined the effect of endurance training on rates of mitochondrial FA oxidation, the activity of carnitine palmitoyltransferase I (CPT I), and the lipid content in muscle of obese individuals and related these to measures of glucose tolerance. Nine obese subjects completed 8 wk of moderate-intensity endurance training, and muscle biopsies were obtained before and after training. Training significantly improved glucose tolerance, with a reduction in the area under the curve for glucose ( P < 0.05) and insulin ( P = 0.01) during an oral glucose tolerance test. CPT I activity increased 250% ( P = 0.001) with training and became less sensitive to inhibition by malonyl-CoA. This was associated with an increase in mitochondrial FA oxidation (+120%, P < 0.001). Training had no effect on muscle triacylglycerol content; however, there was a trend for training to reduce both the total diacylglcyerol (DAG) content (−15%, P = 0.06) and the saturated DAG-FA species (−27%, P = 0.06). Training reduced both total ceramide content (−42%, P = 0.01) and the saturated ceramide species (−32%, P < 0.05). These findings suggest that the improved capacity for mitochondrial FA uptake and oxidation leads not only to a reduction in muscle lipid content but also a to change in the saturation status of lipids, which may, at least in part, provide a mechanism for the enhanced insulin action observed with endurance training in obese individuals.

Overview

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00587.2005

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 41 references

Research works printed but not linked: 1

  1. 10.1210/jcem.86.12.8075 · DOI · Paper page

Cited by

Sorted by citations

Items 201–300 of 327

Related

See all

Metadata

Authors
Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J.
Affiliations
Garvan Institute of Medical Research (AU)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2006-07
Volume
291
Issue
1
Pages
E99-E107
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00587.2005
OpenAlex
W2168588760
Cited by
328
References
41
Citations by year
2026: 6 · 2025: 11 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 19 · 2016: 15 · 2015: 9 · 2014: 18 · 2013: 22 · 2012: 32
FWCI
15.91
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • University of Guelph
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
endurance training, obesity, glucose tolerance, insulin sensitivity, mitochondrial fatty acid oxidation, carnitine palmitoyltransferase 1, malonyl-CoA inhibition, muscle fat content, diacylglycerol, ceramide, triglycerides, fatty acid saturation, insulin resistance
MeSH terms
Adult, Blood Glucose, Carnitine O-Palmitoyltransferase, Citrate (si)-Synthase, Enoyl-CoA Hydratase, Fatty Acids, Female, Glucose Tolerance Test, Humans, Insulin, Male, Mitochondria, Muscle, Obesity, Triglycerides, Blotting, Western, Exercise, Muscle, Skeletal, Area Under Curve, Biopsy, Fine-Needle

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review