The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways
Abstract
Glycogen is the storage form of carbohydrate for virtually every organism from yeast to primates. Most mammalian tissues store glucose as glycogen, with the major depots located in muscle and liver. The French physiologist Claude Bernard first identified a starch-like substance in liver and muscle and coined the term glycogen, or “sugar former,” in the 1850s. During the 150 years since its identification, researchers in the field of glycogen metabolism have made numerous discoveries that are now recognized as significant milestones in biochemistry and cell signaling. Even so, more questions remain, and studies continue to demonstrate the complexity of the regulation of glycogen metabolism. Under classical definitions, the functions of glycogen seem clear: muscle glycogen is degraded to generate ATP during increased energy demand, whereas hepatic glycogen is broken down for release of glucose into the bloodstream to supply other tissues. However, recent findings demonstrate that the roles of glycogen metabolism in energy sensing, integration of metabolic pathways, and coordination of cellular responses to hormonal stimuli are far more complex.
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Cites
Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E., & Wolfe, R. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e380 · Cited by 1,747
Glycogen Synthetase Activity in Skeletal Muscle
Danforth, W. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45214-8 · Cited by 435
New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin
Lawrence, J. C., & Roach, P. J. (1997) · Diabetes · doi:10.2337/diab.46.4.541 · Cited by 311 · cited 1×
“The enzyme is phosphorylated on up to nine residues, resulting in its progressive inactivation and decreased sensitivity to allosteric activators (31).”
Contraction signaling to glucose transport in skeletal muscle
Jessen, N., & Goodyear, L. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00175.2005 · Cited by 311 · cited 2×
“Glucose transport into the muscle is increased, correlated acutely with enhanced GLUT4 translocation to the plasma membrane (24, 52), and, in trained individuals, upregulation of GLUT4 mRNA and protein levels (20, 30).”
Wojtaszewski, J. F. P., Jørgensen, S. B., Hellsten, Y., Hardie, D. G., & Richter, E. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.284 · Cited by 261
The regulation of carbohydrate and fat metabolism during and after exercise
Holloszy, J. O. (1998) · Frontiers in bioscience · doi:10.2741/a342 · Cited by 180
Blomstrand, E., & Saltin, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.293af.x · Cited by 178
Brushia, R. (1999) · Frontiers in bioscience · doi:10.2741/brushia · Cited by 174
Influence of muscle glycogen on glycogenolysis and glucose uptake during exercise in humans
Hargreaves, M., McConell, G., & Proietto, J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.1.288 · Cited by 172 · cited 2×
“Support for the role of glycogen levels in regulating the switch in fuel utilization by muscle during exercise comes from studies where glycogen content was manipulated prior to exercise (1, 2, 9, 18, 65).”
AMP-activated protein kinase: a key system mediating metabolic responses to exercise
HARDIE, D. G. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000106171.38299.64 · Cited by 165
Cited by
Glycogen and its metabolism: some new developments and old themes
Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D., & Tagliabracci, V. S. (2012) · Biochemical Journal · doi:10.1042/bj20111416 · Cited by 709
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
Agarwal, S., Holton, K. L., & Lanza, R. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1102 · Cited by 405
Sheng, H., & Sun, H. (2011) · Natural Product Reports · doi:10.1039/c0np00059k · Cited by 289
Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism
Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. S., & Yamamoto, M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01095-15 · Cited by 126
Biochemical and Clinical Aspects of Glycogen Storage Diseases
Ellingwood, S. S., & Cheng, A. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0120 · Cited by 118
Metadata
- Authors
- Greenberg, C. C., Jurczak, M. J., Danos, A. M., & Brady, M. J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-07
- Volume
- 291
- Issue
- 1
- Pages
- E1-E8
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2121073264
- Cited by
- 183
- References
- 11
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenberg, C. C., Jurczak, M. J., Danos, A. M., & Brady, M. J. (2006). Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00652.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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