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Plasma concentrations of total and free corticosterone during development in the rat.
Abstract
A sensitive protein-binding assay has been used to measure plasma concentrations of total corticosterone during postnatal development in the rat. These concentrations were extremely low on days 6--12, showed a significant rise by day 14, and then continued to rise until peaking on day 24. Plasma titers of corticosteroid-binding globulin rose even more dramatically from day 12 onward. Consequently, the percentage of total plasma corticosterone, which was protein-bound, showed a gradual rise from 78% on day 12 to 98% on day 24. Despite this trend, when concentrations of free corticosterone were calculated, they were found to have a developmental profile very similar to that of total corticosterone. Assay of jejunal lactase and sucrase in the same animals that were used for the corticosterone studies showed that the ontogenic rise of both total and free corticosterone preceded the developmental changes in the activities of these enzymes by approximately 2 days. The data suggest that the rise in free corticosterone that begins on day 14 acts as a cue for enzymic changes in both liver and intestine.
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Citations
Cited by
Sapolsky, R. M., & Meaney, M. J. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90010-x · Cited by 991
Development of Intestinal Transport Function in Mammals
Pácha, J. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1633 · Cited by 398
Stress, genes and the mechanism of programming the brain for later life
de Kloet, E. R., Sibug, R. M., Helmerhorst, F. M., & Schmidt, M. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.008 · Cited by 375
Laviola, G., Adriani, W., Terranova, M. L., & Gerra, G. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00032-9 · Cited by 345
BELLOWS, C. G., AUBIN, J. E., & HEERSCHE, J. N. M. (1987) · Endocrinology · doi:10.1210/endo-121-6-1985 · Cited by 306
Metadata
- Authors
- Henning, S. J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1978-11-01
- Volume
- 235
- Issue
- 5
- Pages
- E451
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2184111416
- Cited by
- 414
- References
- 0
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Henning, S. J. (1978). Plasma concentrations of total and free corticosterone during development in the rat. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1978.235.5.e451
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