Sham feeding-induced cephalic phase insulin release in the rat
Abstract
The effect of the cephalic phase of food ingestion on plasma insulin and glucagon concentration was assessed in the sham-feeding rat, bearing chronically implanted gastric drainage fistulas. It was found that continuous sham feeding produced a significant and phasic peripheral insulin response in the absence of any significant changes of glycemia. The response was almost completely blocked by prior intravenous administration of 2 mg/kg of atropine methyl nitrate and potentiated by prior intravenous administration of 1.0 or 2.5 mg/kg of phentolamine. In spite of the larger insulin response after phentolamine, there was no hypoglycemia detected. Furthermore, continuous sham feeding did not produce a significant glucagon response, whereas real feeling did. The results demonstrate that cholinergic insulin release is triggered phasically by continuous ingestion of familiar food and that this insulin response is inhibited by an alpha-adrenergic sympathetic tone. It is further concluded that the increased glucose disposal produced by the neurally released insulin is not counteracted by a concomitant glucagon response or by direct adrenergic stimulation of hepatic glucose production.
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Insulin release is stimulated by the cephalic phase, a conditioned reflex of increased hormone secretion even in the absence of nutrients/glucose as a trigger, such as when anticipating a meal.
“Likewise, insulin release is stimulated by the so-called cephalic phase, which represents the conditioned reflex of increased hormone secretion, referred to as cephalic phase insulin response,131 even in the absence of nutrients/glucose as a trigger,132, 133, 134 such as when anticipating a meal, to prepare the organism to adequately respond to incoming nutrients.135”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [134]
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Biological Clock Control of Glucose Metabolism
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Ramsay, D. J., Booth, D. A., & Kong, H. (1991) · ILSI Human Nutrition Reviews · doi:10.1007/978-1-4471-1817-6
- Authors
- Berthoud, H. R., & Jeanrenaud, B.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1982-04-01
- Volume
- 242
- Issue
- 4
- Pages
- E280-E285
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1843212988
- Cited by
- 103
- References
- 18
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- sham feeding, glucagon, phentolamine, atropine methyl nitrate, sympathetic tone, glucose disposal, hepatic glucose production, food ingestion
- MeSH terms
- Insulin Secretion, Animals, Atropine, Blood Glucose, Diet, Eating, Gastric Fistula, Insulin, Kinetics, Male, Phentolamine, Rats, Inbred Strains, Stomach, Rats
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