The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
Abstract
Contractile function and substrate metabolism were characterized in perfused hearts from genetically diabetic C57BL/KsJ- lepr db/ lepr db( db/db) mice and their non-diabetic lean littermates. Contractility was assessed in working hearts by measuring left ventricular pressures and cardiac power. Rates of glycolysis, glucose oxidation, and fatty acid oxidation were measured using radiolabeled substrates ([5-3 H]glucose, [U-14 C]glucose, and [9,10-3 H]palmitate) in the perfusate. Contractile dysfunction in db/db hearts was evident, with increased left ventricular end diastolic pressure and decreased left ventricular developed pressure, cardiac output, and cardiac power. The rate of glycolysis from exogenous glucose in diabetic hearts was 48% of control, whereas glucose oxidation was depressed to only 16% of control. In contrast, palmitate oxidation was increased twofold in db/db hearts. The hypothesis that altered metabolism plays a causative role in diabetes-induced contractile dysfunction was tested using perfused hearts from transgenic db/db mice that overexpress GLUT-4 glucose transporters. Both glucose metabolism and palmitate metabolism were normalized in hearts from db/db-human insulin-regulatable glucose transporter (hGLUT-4) hearts, as was contractile function. These findings strongly support a causative role of impaired metabolism in the cardiomyopathy observed in db/db diabetic hearts.
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Citations
Cites
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Regulation of energy substrate metabolism in the diabetic heart
Stanley, W. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00047-3 · Cited by 480
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Cited by
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543
Molecular mechanisms of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3171-6 · Cited by 903
Buchanan, J., Mazumder, P. K., Hu, P., Chakrabarti, G., Roberts, M. W., Yun, U. J., Cooksey, R. C., Litwin, S. E., & Abel, E. D. (2005) · Endocrinology · doi:10.1210/en.2005-0938 · Cited by 555
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Metadata
- Authors
- Belke, D. D., Larsen, T. S., Gibbs, E. M., & Severson, D. L.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2000-11-01
- Volume
- 279
- Issue
- 5
- Pages
- E1104-E1113
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2106411160
- Cited by
- 401
- References
- 36
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Belke, D. D., Larsen, T. S., Gibbs, E. M., & Severson, D. L. (2000). Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.2000.279.5.e1104
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