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Cited by 375

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Intestinal digestive resistance of immunodominant gliadin peptides

Hausch, Felix, Shan, Lu, Santiago, Nilda A., Gray, Gary M., Khosla, Chaitan·2002·American Journal of Physiology-Gastrointestinal and Liver Physiology
DOI 10.1152/ajpgi.00136.2002
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Abstract

Two recently identified immunodominant epitopes from α-gliadin account for most of the stimulatory activity of dietary gluten on intestinal and peripheral T lymphocytes in patients with celiac sprue. The proteolytic kinetics of peptides containing these epitopes were analyzed in vitro using soluble proteases from bovine and porcine pancreas and brush-border membrane vesicles from adult rat intestine. We showed that these proline-glutamine-rich epitopes are exceptionally resistant to enzymatic processing. Moreover, as estimated from the residual peptide structure and confirmed by exogeneous peptidase supplementation, dipeptidyl peptidase IV and dipeptidyl carboxypeptidase I were identified as the rate-limiting enzymes in the digestive breakdown of these peptides. A similar conclusion also emerged from analogous studies with brush-border membrane from a human intestinal biopsy. Supplementation of rat brush-border membrane with trace quantities of a bacterial prolyl endopeptidase led to the rapid destruction of the immunodominant epitopes in these peptides. These results suggest a possible enzyme therapy strategy for celiac sprue, for which the only current therapeutic option is strict exclusion of gluten-containing food.

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Metadata

Authors
Hausch, F., Shan, L., Santiago, N. A., Gray, G. M., & Khosla, C.
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Published
2002-10-01
Volume
283
Issue
4
Pages
G996-G1003
ISSN
  • 0193-1857 (ISSN-L)
  • 1522-1547
DOI
10.1152/ajpgi.00136.2002
OpenAlex
W2168800337
Cited by
375
References
17
FWCI
10.60
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Intestinal digestive resistance of immunodominant gliadin peptides. https://app.cochat.ai/papers/10.1152/ajpgi.00136.2002
The paper
Hausch, F., Shan, L., Santiago, N. A., Gray, G. M., & Khosla, C. (2002). Intestinal digestive resistance of immunodominant gliadin peptides. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00136.2002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.